BDBM50533340 CHEMBL4585935
SMILES: OC1(CC2CCC(C1)N2C(c1ccccc1Cl)c1ccccc1Cl)c1ncccn1
InChI Key: InChIKey=MQWMHMZNBGQNMT-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Nociceptin receptor (Homo sapiens (Human)) | BDBM50533340![]() (CHEMBL4585935) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | 4.60 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astraea Therapeutics Curated by ChEMBL | Assay Description Displacement of [125I][Tyr14]nociceptin/orphanin FQ from human nociceptin opioid receptor expressed in CHO cell membranes after 1 hr by microplate sc... | J Med Chem 59: 7011-28 (2016) Article DOI: 10.1021/acs.jmedchem.5b01499 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Mu-type opioid receptor (Homo sapiens (Human)) | BDBM50533340![]() (CHEMBL4585935) | PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | 972 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
Astraea Therapeutics Curated by ChEMBL | Assay Description Displacement of [3H]diprenorphine from human mu opioid receptor expressed in CHO cell membranes after 1 hr by microplate scintillation counting metho... | J Med Chem 59: 7011-28 (2016) Article DOI: 10.1021/acs.jmedchem.5b01499 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Nociceptin receptor (Homo sapiens (Human)) | BDBM50533340![]() (CHEMBL4585935) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | n/a | n/a | 79 | n/a | n/a | n/a | n/a |
Astraea Therapeutics Curated by ChEMBL | Assay Description Agonist activity at human nociceptin opioid receptor expressed in CHO cell membranes after 30 mins by GTPgamma(35)S binding assay | J Med Chem 59: 7011-28 (2016) Article DOI: 10.1021/acs.jmedchem.5b01499 | |||||||||||
More data for this Ligand-Target Pair |