BDBM50533353 CHEMBL4549947

SMILES: Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1

InChI Key: InChIKey=GZWREPINEZUJGH-UHFFFAOYSA-N

Data: 6 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50533353   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50533353 (CHEMBL4549947) Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1 Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	700	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50533353 (CHEMBL4549947) Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1 Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of polymerase activity of HIV1 reverse transcriptase using poly(rA)-oligo(dT)16 and [3H]-TTP incubated for 20 mins by liquid scintillation...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50533353 (CHEMBL4549947) Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1 Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	500	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50533353 (CHEMBL4549947) Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1 Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879
					More data for this Ligand-Target Pair
Human immunodeficiency virus type 1 reverse transcriptase (Human immunodeficiency virus 1)	BDBM50533353 (CHEMBL4549947) Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1 Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	400	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879
					More data for this Ligand-Target Pair
Integrase (Human immunodeficiency virus 1)	BDBM50533353 (CHEMBL4549947) Show SMILES Cc1ccc(cc1)-c1ccc(Nc2cc(=O)n(O)c(=O)[nH]2)cc1 Show InChI InChI=1S/C17H15N3O3/c1-11-2-4-12(5-3-11)13-6-8-14(9-7-13)18-15-10-16(21)20(23)17(22)19-15/h2-10,18,23H,1H3,(H,19,22)	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	9.30E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV integrase pre-incubated for 10 mins before addition of oligo-5'-biotin ATGTGGAAAATCTCTAGCA annealed with ACTGCTAGAGATTTTCCACAT 3'-C...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879
					More data for this Ligand-Target Pair