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SMILES: COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1

InChI Key: InChIKey=XRZDPBCHSTWHKX-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533355   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533355 (CHEMBL4437367) Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C18H17N3O4/c1-20-16(11-17(22)21(24)18(20)23)19-14-8-6-12(7-9-14)13-4-3-5-15(10-13)25-2/h3-11,19,24H,1-2H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533355 (CHEMBL4437367) Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C18H17N3O4/c1-20-16(11-17(22)21(24)18(20)23)19-14-8-6-12(7-9-14)13-4-3-5-15(10-13)25-2/h3-11,19,24H,1-2H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of re-constituted HIV1 reverse transcriptase RNase H domain fragment				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533355 (CHEMBL4437367) Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C18H17N3O4/c1-20-16(11-17(22)21(24)18(20)23)19-14-8-6-12(7-9-14)13-4-3-5-15(10-13)25-2/h3-11,19,24H,1-2H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	800	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533355 (CHEMBL4437367) Show SMILES COc1cccc(c1)-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C18H17N3O4/c1-20-16(11-17(22)21(24)18(20)23)19-14-8-6-12(7-9-14)13-4-3-5-15(10-13)25-2/h3-11,19,24H,1-2H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair