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SMILES: Cc1noc(C)c1-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1

InChI Key: InChIKey=FEMHLBIUWZWUNR-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533371   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Integrase (Human immunodeficiency virus 1)	BDBM50533371 (CHEMBL4437185) Show SMILES Cc1noc(C)c1-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C16H16N4O4/c1-9-15(10(2)24-18-9)11-4-6-12(7-5-11)17-13-8-14(21)20(23)16(22)19(13)3/h4-8,17,23H,1-3H3	PDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.50E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of HIV integrase pre-incubated for 10 mins before addition of oligo-5'-biotin ATGTGGAAAATCTCTAGCA annealed with ACTGCTAGAGATTTTCCACAT 3'-C...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533371 (CHEMBL4437185) Show SMILES Cc1noc(C)c1-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C16H16N4O4/c1-9-15(10(2)24-18-9)11-4-6-12(7-5-11)17-13-8-14(21)20(23)16(22)19(13)3/h4-8,17,23H,1-3H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533371 (CHEMBL4437185) Show SMILES Cc1noc(C)c1-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C16H16N4O4/c1-9-15(10(2)24-18-9)11-4-6-12(7-5-11)17-13-8-14(21)20(23)16(22)19(13)3/h4-8,17,23H,1-3H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533371 (CHEMBL4437185) Show SMILES Cc1noc(C)c1-c1ccc(Nc2cc(=O)n(O)c(=O)n2C)cc1 Show InChI InChI=1S/C16H16N4O4/c1-9-15(10(2)24-18-9)11-4-6-12(7-5-11)17-13-8-14(21)20(23)16(22)19(13)3/h4-8,17,23H,1-3H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.40E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair