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SMILES: Cn1c(Nc2cccc(c2)-c2ccc(O)cc2)cc(=O)n(O)c1=O

InChI Key: InChIKey=PEJQTYSZESCDHT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50533383   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533383 (CHEMBL4471917) Show SMILES Cn1c(Nc2cccc(c2)-c2ccc(O)cc2)cc(=O)n(O)c1=O Show InChI InChI=1S/C17H15N3O4/c1-19-15(10-16(22)20(24)17(19)23)18-13-4-2-3-12(9-13)11-5-7-14(21)8-6-11/h2-10,18,21,24H,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.70E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in RNA 5'-end directed cleavage using HTS3...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533383 (CHEMBL4471917) Show SMILES Cn1c(Nc2cccc(c2)-c2ccc(O)cc2)cc(=O)n(O)c1=O Show InChI InChI=1S/C17H15N3O4/c1-19-15(10-16(22)20(24)17(19)23)18-13-4-2-3-12(9-13)11-5-7-14(21)8-6-11/h2-10,18,21,24H,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	750	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in nonspecific internal cleavage using HTS...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase/RNaseH (Human immunodeficiency virus 1)	BDBM50533383 (CHEMBL4471917) Show SMILES Cn1c(Nc2cccc(c2)-c2ccc(O)cc2)cc(=O)n(O)c1=O Show InChI InChI=1S/C17H15N3O4/c1-19-15(10-16(22)20(24)17(19)23)18-13-4-2-3-12(9-13)11-5-7-14(21)8-6-11/h2-10,18,21,24H,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD DrugBank GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.80E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of RNase H activity of full length recombinant HIV1 reverse transcriptase assessed as reduction in DNA 3'-end cleavage using HTS2 substrat...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair
Reverse transcriptase (Human immunodeficiency virus 1)	BDBM50533383 (CHEMBL4471917) Show SMILES Cn1c(Nc2cccc(c2)-c2ccc(O)cc2)cc(=O)n(O)c1=O Show InChI InChI=1S/C17H15N3O4/c1-19-15(10-16(22)20(24)17(19)23)18-13-4-2-3-12(9-13)11-5-7-14(21)8-6-11/h2-10,18,21,24H,1H3	PDB MMDB UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Minnesota Curated by ChEMBL					Assay Description Inhibition of polymerase activity of HIV1 reverse transcriptase using poly(rA)-oligo(dT)16 and [3H]-TTP incubated for 20 mins by liquid scintillation...				J Med Chem 59: 2648-59 (2016) Article DOI: 10.1021/acs.jmedchem.5b01879 BindingDB Entry DOI: 10.7270/Q2QN6B8P
					More data for this Ligand-Target Pair