null

SMILES: Cc1nn(CCCC(F)(F)F)nc1-c1ncnc2[nH]ccc12

InChI Key: InChIKey=GAPKEGFKKBWQLO-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50533707   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50533707 (CHEMBL4537821) Show SMILES Cc1nn(CCCC(F)(F)F)nc1-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C13H13F3N6/c1-8-10(11-9-3-5-17-12(9)19-7-18-11)21-22(20-8)6-2-4-13(14,15)16/h3,5,7H,2,4,6H2,1H3,(H,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	96	n/a	n/a	n/a	n/a	n/a	n/a
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL					Assay Description Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...				Bioorg Med Chem 24: 5036-5046 (2016) Article DOI: 10.1016/j.bmc.2016.08.008
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK1 (Homo sapiens (Human))	BDBM50533707 (CHEMBL4537821) Show SMILES Cc1nn(CCCC(F)(F)F)nc1-c1ncnc2[nH]ccc12 Show InChI InChI=1S/C13H13F3N6/c1-8-10(11-9-3-5-17-12(9)19-7-18-11)21-22(20-8)6-2-4-13(14,15)16/h3,5,7H,2,4,6H2,1H3,(H,17,18,19)	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	82	n/a	n/a	n/a	n/a	n/a	n/a
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL					Assay Description Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting method				Bioorg Med Chem 24: 5036-5046 (2016) Article DOI: 10.1016/j.bmc.2016.08.008
					More data for this Ligand-Target Pair