null
SMILES: Cc1nn(CC2CC2)nc1-c1ncnc2[nH]ccc12
InChI Key: InChIKey=LOHDDGKYDGJSDH-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Tyrosine-protein kinase JAK1 (Homo sapiens (Human)) | BDBM50533709 (CHEMBL4564551) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 444 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Inhibition of human JAK1 using GEEPLYWSFPAKKK as substrate measured after 40 mins in presence of ATP by scintillation counting method | Bioorg Med Chem 24: 5036-5046 (2016) Article DOI: 10.1016/j.bmc.2016.08.008 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK3 (Homo sapiens (Human)) | BDBM50533709 (CHEMBL4564551) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 2.44E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Inhibition of JAK3 (unknown origin) measured after 1 hr in presence of ATP by TR-FRET assay | Bioorg Med Chem 24: 5036-5046 (2016) Article DOI: 10.1016/j.bmc.2016.08.008 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tyrosine-protein kinase JAK2 (Homo sapiens (Human)) | BDBM50533709 (CHEMBL4564551) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 42 | n/a | n/a | n/a | n/a | n/a | n/a |
Gwangju Institute of Science and Technology (GIST) Curated by ChEMBL | Assay Description Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b... | Bioorg Med Chem 24: 5036-5046 (2016) Article DOI: 10.1016/j.bmc.2016.08.008 | |||||||||||
More data for this Ligand-Target Pair |