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SMILES: Cc1nn(CC2CCC2)nc1-c1ncnc2[nH]ccc12

InChI Key: InChIKey=RGXVBQLCSJDAAC-UHFFFAOYSA-N

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50533711   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Tyrosine-protein kinase JAK2


(Homo sapiens (Human))		BDBM50533711
PNG
(CHEMBL4460736)
Show SMILES Cc1nn(CC2CCC2)nc1-c1ncnc2[nH]ccc12
Show InChI InChI=1S/C14H16N6/c1-9-12(19-20(18-9)7-10-3-2-4-10)13-11-5-6-15-14(11)17-8-16-13/h5-6,8,10H,2-4,7H2,1H3,(H,15,16,17)
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n/an/a 63n/an/an/an/an/an/a



Gwangju Institute of Science and Technology (GIST)

Curated by ChEMBL


Assay Description
Inhibition of recombinant human C-terminal 6His-tagged JAK2 (808 to end amino acids) expressed in Sf21 cells measured after 1 hr in presence of ATP b...

Bioorg Med Chem 24: 5036-5046 (2016)


Article DOI: 10.1016/j.bmc.2016.08.008
More data for this
Ligand-Target Pair