Found 9 hits for monomerid = 50533776 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.56E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kalpha expressed in rat-1 fibroblasts assessed as reduction in Akt phosphorylation at Ser 473 after 1 hr by alphascreen assay |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 4.15E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3Kbeta (unknown origin) using phosphatidyl inositol as substrate after 30 to 60 mins in presence of ATP by Kinase Glo lum... |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 20 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta (unknown origin) assessed as reduction in ADP formation using phosphatidyl inositol as substrate after 30 to 60 mins by TR-FR... |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.91E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kbeta expressed in rat-1 fibroblasts assessed as reduction in Akt phosphorylation at Ser 473 after 1 hr by alphascreen assay |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 7.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kgamma (unknown origin) assessed as reduction in ADP formation using phosphatidyl inositol as substrate after 30 to 60 mins by TR-FR... |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 259 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of recombinant PI3Kalpha (unknown origin) using phosphatidyl inositol as substrate after 30 to 60 mins in presence of ATP by Kinase Glo lu... |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
PI3K p110 delta/p85 alpha
(Mus musculus (Mouse)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 87 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of PI3Kdelta in Balb/c mouse B cells assessed as reduction in anti-IgM induced CD86 expression preincubated for 1 hr followed by anti-IgM ... |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
1,3-beta-glucan synthase component GLS2
(Saccharomyces cerevisiae) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | KEGG
UniProtKB/SwissProt
GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 1.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Displacement of [3H]dofetilide from recombinant human ERG transfected in HEK293 cell membranes after 60 mins by scintillation counting |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50533776
![PNG](/data/jpeg/tenK5053/BindingDB_50533776.png) (CHEMBL4581278)Show SMILES COc1ccc(cn1)-c1ccc2ncnc(-c3cccc(c3)C(=O)N3CCN(C)CC3)c2c1 Show InChI InChI=1S/C26H25N5O2/c1-30-10-12-31(13-11-30)26(32)20-5-3-4-19(14-20)25-22-15-18(6-8-23(22)28-17-29-25)21-7-9-24(33-2)27-16-21/h3-9,14-17H,10-13H2,1-2H3 | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![](/images/AffyNet_logo.png)
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 37 | n/a | n/a | n/a | n/a | n/a | n/a |
Novartis Institutes for BioMedical Research
Curated by ChEMBL
| Assay Description Inhibition of human PI3Kdelta expressed in rat-1 fibroblasts assessed as reduction in Akt phosphorylation at Ser 473 after 1 hr by alphascreen assay |
ACS Med Chem Lett 7: 762-7 (2016)
Article DOI: 10.1021/acsmedchemlett.6b00119 |
More data for this Ligand-Target Pair | |