null

SMILES: OC(=O)c1ccc(cc1)C(=O)N1CCc2nc3CCCCn3c(=O)c2C1

InChI Key: InChIKey=JLUHGDBGYVYCNZ-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50535652   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
C-1-tetrahydrofolate synthase, cytoplasmic (Homo sapiens (Human))	BDBM50535652 (CHEMBL4547499) Show SMILES OC(=O)c1ccc(cc1)C(=O)N1CCc2nc3CCCCn3c(=O)c2C1 Show InChI InChI=1S/C19H19N3O4/c23-17(12-4-6-13(7-5-12)19(25)26)21-10-8-15-14(11-21)18(24)22-9-2-1-3-16(22)20-15/h4-7H,1-3,8-11H2,(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...				ACS Med Chem Lett 10: 893-898 (2019) Article DOI: 10.1021/acsmedchemlett.9b00069
					More data for this Ligand-Target Pair
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (Homo sapiens (Human))	BDBM50535652 (CHEMBL4547499) Show SMILES OC(=O)c1ccc(cc1)C(=O)N1CCc2nc3CCCCn3c(=O)c2C1 Show InChI InChI=1S/C19H19N3O4/c23-17(12-4-6-13(7-5-12)19(25)26)21-10-8-15-14(11-21)18(24)22-9-2-1-3-16(22)20-15/h4-7H,1-3,8-11H2,(H,25,26)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...				ACS Med Chem Lett 10: 893-898 (2019) Article DOI: 10.1021/acsmedchemlett.9b00069
					More data for this Ligand-Target Pair