null

SMILES: Cn1c(nc2CCN(Cc2c1=O)C(=O)c1ccc(cc1)C(O)=O)-c1ccccc1

InChI Key: InChIKey=MLEXZDDSAFOKBW-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50535655   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (Homo sapiens (Human))	BDBM50535655 (CHEMBL4440948) Show SMILES Cn1c(nc2CCN(Cc2c1=O)C(=O)c1ccc(cc1)C(O)=O)-c1ccccc1 Show InChI InChI=1S/C22H19N3O4/c1-24-19(14-5-3-2-4-6-14)23-18-11-12-25(13-17(18)21(24)27)20(26)15-7-9-16(10-8-15)22(28)29/h2-10H,11-13H2,1H3,(H,28,29)	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.40E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant MTHFD2 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NAD and formaldehyde incuba...				ACS Med Chem Lett 10: 893-898 (2019) Article DOI: 10.1021/acsmedchemlett.9b00069
					More data for this Ligand-Target Pair
C-1-tetrahydrofolate synthase, cytoplasmic (Homo sapiens (Human))	BDBM50535655 (CHEMBL4440948) Show SMILES Cn1c(nc2CCN(Cc2c1=O)C(=O)c1ccc(cc1)C(O)=O)-c1ccccc1 Show InChI InChI=1S/C22H19N3O4/c1-24-19(14-5-3-2-4-6-14)23-18-11-12-25(13-17(18)21(24)27)20(26)15-7-9-16(10-8-15)22(28)29/h2-10H,11-13H2,1H3,(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Daiichi Sankyo Co., Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant MTHFD1 (unknown origin) assessed as reduction in methenyl-THF formation using tetrahydrofolate, NADP and formaldehyde incub...				ACS Med Chem Lett 10: 893-898 (2019) Article DOI: 10.1021/acsmedchemlett.9b00069
					More data for this Ligand-Target Pair