BDBM50535755 CHEMBL4519255

SMILES: Cc1ccc(NCc2nc(-c3cc4cnccc4s3)c([nH]2)-c2cccc(C)n2)cc1

InChI Key: InChIKey=HXZZGSJNQKWJEX-UHFFFAOYSA-N

Data: 2 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50535755   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
TGF-beta receptor type-1 (Homo sapiens (Human))	BDBM50535755 (CHEMBL4519255) Show SMILES Cc1ccc(NCc2nc(-c3cc4cnccc4s3)c([nH]2)-c2cccc(C)n2)cc1 Show InChI InChI=1S/C24H21N5S/c1-15-6-8-18(9-7-15)26-14-22-28-23(19-5-3-4-16(2)27-19)24(29-22)21-12-17-13-25-11-10-20(17)30-21/h3-13,26H,14H2,1-2H3,(H,28,29)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	43	n/a	n/a	n/a	n/a	n/a	n/a
Yanbian University Curated by ChEMBL					Assay Description Inhibition of human recombinant GST-tagged ALK5 expressed in Sf9 insect cells using casein as substrate incubated for 60 mins in presence of [33P]-AT...				Bioorg Med Chem Lett 29: 2070-2075 (2019) Article DOI: 10.1016/j.bmcl.2019.07.015
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 14 (Homo sapiens (Human))	BDBM50535755 (CHEMBL4519255) Show SMILES Cc1ccc(NCc2nc(-c3cc4cnccc4s3)c([nH]2)-c2cccc(C)n2)cc1 Show InChI InChI=1S/C24H21N5S/c1-15-6-8-18(9-7-15)26-14-22-28-23(19-5-3-4-16(2)27-19)24(29-22)21-12-17-13-25-11-10-20(17)30-21/h3-13,26H,14H2,1-2H3,(H,28,29)	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Yanbian University Curated by ChEMBL					Assay Description Inhibition of human recombinant untagged p38alpha expressed in Escherichia coli using ATF2 as substrate incubated for 60 mins in presence of [33P]-AT...				Bioorg Med Chem Lett 29: 2070-2075 (2019) Article DOI: 10.1016/j.bmcl.2019.07.015
					More data for this Ligand-Target Pair