Found 5 hits for monomerid = 50535966 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Serine-protein kinase ATM
(Homo sapiens (Human)) | BDBM50535966
(CHEMBL4560522)Show SMILES CCC(CC)CNc1c(cnc2ccc(cc12)-c1ccc(COC)nc1)C(N)=O Show InChI InChI=1S/C23H28N4O2/c1-4-15(5-2)11-27-22-19-10-16(17-6-8-18(14-29-3)25-12-17)7-9-21(19)26-13-20(22)23(24)28/h6-10,12-13,15H,4-5,11,14H2,1-3H3,(H2,24,28)(H,26,27) | PDB
UniProtKB/SwissProt
UniProtKB/TrEMBL
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 45 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based... |
J Med Chem 59: 6281-92 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00519 |
More data for this
Ligand-Target Pair | |
Glycogen synthase kinase-3 beta
(Homo sapiens (Human)) | BDBM50535966
(CHEMBL4560522)Show SMILES CCC(CC)CNc1c(cnc2ccc(cc12)-c1ccc(COC)nc1)C(N)=O Show InChI InChI=1S/C23H28N4O2/c1-4-15(5-2)11-27-22-19-10-16(17-6-8-18(14-29-3)25-12-17)7-9-21(19)26-13-20(22)23(24)28/h6-10,12-13,15H,4-5,11,14H2,1-3H3,(H2,24,28)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >1.00E+5 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of GSK3beta (unknown origin) |
J Med Chem 59: 6281-92 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00519 |
More data for this
Ligand-Target Pair | |
1,3-beta-glucan synthase component GLS2
(Saccharomyces cerevisiae) | BDBM50535966
(CHEMBL4560522)Show SMILES CCC(CC)CNc1c(cnc2ccc(cc12)-c1ccc(COC)nc1)C(N)=O Show InChI InChI=1S/C23H28N4O2/c1-4-15(5-2)11-27-22-19-10-16(17-6-8-18(14-29-3)25-12-17)7-9-21(19)26-13-20(22)23(24)28/h6-10,12-13,15H,4-5,11,14H2,1-3H3,(H2,24,28)(H,26,27) | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 2.50E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of human ERG by electrophysiology assay |
J Med Chem 59: 6281-92 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00519 |
More data for this
Ligand-Target Pair | |
Serine/threonine-protein kinase ATR
(Homo sapiens (Human)) | BDBM50535966
(CHEMBL4560522)Show SMILES CCC(CC)CNc1c(cnc2ccc(cc12)-c1ccc(COC)nc1)C(N)=O Show InChI InChI=1S/C23H28N4O2/c1-4-15(5-2)11-27-22-19-10-16(17-6-8-18(14-29-3)25-12-17)7-9-21(19)26-13-20(22)23(24)28/h6-10,12-13,15H,4-5,11,14H2,1-3H3,(H2,24,28)(H,26,27) | PDB
Reactome pathway
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of ATR in human HT-29 cells assessed as reduction in Chk1 phosphorylation at Ser-345 residue after 60 mins in presence of 4-nitroquinoline... |
J Med Chem 59: 6281-92 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00519 |
More data for this
Ligand-Target Pair | |
Vascular endothelial growth factor receptor 2
(Homo sapiens (Human)) | BDBM50535966
(CHEMBL4560522)Show SMILES CCC(CC)CNc1c(cnc2ccc(cc12)-c1ccc(COC)nc1)C(N)=O Show InChI InChI=1S/C23H28N4O2/c1-4-15(5-2)11-27-22-19-10-16(17-6-8-18(14-29-3)25-12-17)7-9-21(19)26-13-20(22)23(24)28/h6-10,12-13,15H,4-5,11,14H2,1-3H3,(H2,24,28)(H,26,27) | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 8.20E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
AstraZeneca
Curated by ChEMBL
| Assay Description
Inhibition of KDR (unknown origin) |
J Med Chem 59: 6281-92 (2016)
Article DOI: 10.1021/acs.jmedchem.6b00519 |
More data for this
Ligand-Target Pair | |
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