null

SMILES: NC(=O)c1cnc2c(Cl)cc(cc2c1NC1CCOCC1)-c1cccnc1

InChI Key: InChIKey=QDVUQPDAAVQTTI-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50535993   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine-protein kinase ATM (Homo sapiens (Human))	BDBM50535993 (CHEMBL4536989) Show SMILES NC(=O)c1cnc2c(Cl)cc(cc2c1NC1CCOCC1)-c1cccnc1 Show InChI InChI=1S/C20H19ClN4O2/c21-17-9-13(12-2-1-5-23-10-12)8-15-18(25-14-3-6-27-7-4-14)16(20(22)26)11-24-19(15)17/h1-2,5,8-11,14H,3-4,6-7H2,(H2,22,26)(H,24,25)	PDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of ATM phosphorylation at Ser-1981 residue in human HT-29 cells incubated for 1 hr followed by X-ray irradiation by Hoechst staining based...				J Med Chem 59: 6281-92 (2016) Article DOI: 10.1021/acs.jmedchem.6b00519 BindingDB Entry DOI: 10.7270/Q2NV9NR8
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase ATR (Homo sapiens (Human))	BDBM50535993 (CHEMBL4536989) Show SMILES NC(=O)c1cnc2c(Cl)cc(cc2c1NC1CCOCC1)-c1cccnc1 Show InChI InChI=1S/C20H19ClN4O2/c21-17-9-13(12-2-1-5-23-10-12)8-15-18(25-14-3-6-27-7-4-14)16(20(22)26)11-24-19(15)17/h1-2,5,8-11,14H,3-4,6-7H2,(H2,22,26)(H,24,25)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>3.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of ATR in human HT-29 cells assessed as reduction in Chk1 phosphorylation at Ser-345 residue after 60 mins in presence of 4-nitroquinoline...				J Med Chem 59: 6281-92 (2016) Article DOI: 10.1021/acs.jmedchem.6b00519 BindingDB Entry DOI: 10.7270/Q2NV9NR8
					More data for this Ligand-Target Pair
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human))	BDBM50535993 (CHEMBL4536989) Show SMILES NC(=O)c1cnc2c(Cl)cc(cc2c1NC1CCOCC1)-c1cccnc1 Show InChI InChI=1S/C20H19ClN4O2/c21-17-9-13(12-2-1-5-23-10-12)8-15-18(25-14-3-6-27-7-4-14)16(20(22)26)11-24-19(15)17/h1-2,5,8-11,14H,3-4,6-7H2,(H2,22,26)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of human ERG by electrophysiology assay				J Med Chem 59: 6281-92 (2016) Article DOI: 10.1021/acs.jmedchem.6b00519 BindingDB Entry DOI: 10.7270/Q2NV9NR8
					More data for this Ligand-Target Pair