BDBM50536091 CHEMBL4527131

SMILES: Cc1nc2cccc(-c3cc4CNC(=O)c4s3)c2nc1NC(C)(C)C

InChI Key: InChIKey=JILYBMJSGXWKEA-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50536091   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50536091 (CHEMBL4527131) Show SMILES Cc1nc2cccc(-c3cc4CNC(=O)c4s3)c2nc1NC(C)(C)C Show InChI InChI=1S/C19H20N4OS/c1-10-17(23-19(2,3)4)22-15-12(6-5-7-13(15)21-10)14-8-11-9-20-18(24)16(11)25-14/h5-8H,9H2,1-4H3,(H,20,24)(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM50536091 (CHEMBL4527131) Show SMILES Cc1nc2cccc(-c3cc4CNC(=O)c4s3)c2nc1NC(C)(C)C Show InChI InChI=1S/C19H20N4OS/c1-10-17(23-19(2,3)4)22-15-12(6-5-7-13(15)21-10)14-8-11-9-20-18(24)16(11)25-14/h5-8H,9H2,1-4H3,(H,20,24)(H,22,23)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.38E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50536091 (CHEMBL4527131) Show SMILES Cc1nc2cccc(-c3cc4CNC(=O)c4s3)c2nc1NC(C)(C)C Show InChI InChI=1S/C19H20N4OS/c1-10-17(23-19(2,3)4)22-15-12(6-5-7-13(15)21-10)14-8-11-9-20-18(24)16(11)25-14/h5-8H,9H2,1-4H3,(H,20,24)(H,22,23)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.5	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair