BDBM50536095 CHEMBL4587596

SMILES: Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)C

InChI Key: InChIKey=YIZTXYBSHMFWTH-UHFFFAOYSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50536095   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50536095 (CHEMBL4587596) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H22FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-6,9,24H,7-8H2,1-4H3,(H,22,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase PIM (Homo sapiens (Human))	BDBM50536095 (CHEMBL4587596) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H22FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-6,9,24H,7-8H2,1-4H3,(H,22,27)(H,25,26)	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	23	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50536095 (CHEMBL4587596) Show SMILES Cc1nc2ccc(F)c(-c3cc4c(CCNC4=O)[nH]3)c2nc1NC(C)(C)C Show InChI InChI=1S/C20H22FN5O/c1-10-18(26-20(2,3)4)25-17-14(23-10)6-5-12(21)16(17)15-9-11-13(24-15)7-8-22-19(11)27/h5-6,9,24H,7-8H2,1-4H3,(H,22,27)(H,25,26)	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.300	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair