BDBM50536100 CHEMBL4522524

SMILES: C[C@H]1NC(=O)c2cc([nH]c12)-c1cccn2c1nc(NC(C)(C)C)c(C)c2=O

InChI Key: InChIKey=YYXJSPFGMAXZGZ-LLVKDONJSA-N

Data: 3 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50536100   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase pim-1 (Homo sapiens (Human))	BDBM50536100 (CHEMBL4522524) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccn2c1nc(NC(C)(C)C)c(C)c2=O |r| Show InChI InChI=1S/C20H23N5O2/c1-10-16(24-20(3,4)5)23-17-12(7-6-8-25(17)19(10)27)14-9-13-15(22-14)11(2)21-18(13)26/h6-9,11,22,24H,1-5H3,(H,21,26)/t11-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-1 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-1/pim-2/pim-3 (Homo sapiens (Human))	BDBM50536100 (CHEMBL4522524) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccn2c1nc(NC(C)(C)C)c(C)c2=O |r| Show InChI InChI=1S/C20H23N5O2/c1-10-16(24-20(3,4)5)23-17-12(7-6-8-25(17)19(10)27)14-9-13-15(22-14)11(2)21-18(13)26/h6-9,11,22,24H,1-5H3,(H,21,26)/t11-/m1/s1	PDB MMDB UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>2.00E+3	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of pan Pim in human KMS-12-BM cells assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 residue after 110 m...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase pim-2 (Homo sapiens (Human))	BDBM50536100 (CHEMBL4522524) Show SMILES C[C@H]1NC(=O)c2cc([nH]c12)-c1cccn2c1nc(NC(C)(C)C)c(C)c2=O |r| Show InChI InChI=1S/C20H23N5O2/c1-10-16(24-20(3,4)5)23-17-12(7-6-8-25(17)19(10)27)14-9-13-15(22-14)11(2)21-18(13)26/h6-9,11,22,24H,1-5H3,(H,21,26)/t11-/m1/s1	PDB MMDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2.10	n/a	n/a	n/a	n/a	n/a	n/a
Amgen Inc. Curated by ChEMBL					Assay Description Inhibition of full length recombinant Pim-2 (unknown origin) assessed as reduction in phosphorylation of biotinylated-BAD peptide at Serine 112 resid...				J Med Chem 59: 6407-30 (2016) Article DOI: 10.1021/acs.jmedchem.6b00610
					More data for this Ligand-Target Pair