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BDBM50537011 CHEMBL4593176

SMILES: CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)NC

InChI Key: InChIKey=CEILGBOGIPKMAN-UHFFFAOYSA-N

Data: 1 IC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50537011   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Prostaglandin E2 receptor


(Homo sapiens (Human))		BDBM50537011
PNG
(CHEMBL4593176)
Show SMILES CCn1c2ccccc2c2cc(ccc12)-c1nc2cc(ccc2n1CC1CC1)C(=O)NC
Show InChI InChI=1S/C27H26N4O/c1-3-30-23-7-5-4-6-20(23)21-14-18(10-12-24(21)30)26-29-22-15-19(27(32)28-2)11-13-25(22)31(26)16-17-8-9-17/h4-7,10-15,17H,3,8-9,16H2,1-2H3,(H,28,32)
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Bayer AG

Curated by ChEMBL


Assay Description
Antagonist activity at human EP4R assessed as inhibition of agonist-induced cAMP production by fluorescent cAMP tracer cAMP-d2 based FRET assay

J Med Chem 62: 2541-2563 (2019)


Article DOI: 10.1021/acs.jmedchem.8b01862
More data for this
Ligand-Target Pair