BDBM50537733 CHEMBL4639546
SMILES: CCC(=O)N1CCN(C[C@H]1C)c1nc(ncc1C#N)-c1cnn(C)c1
InChI Key: InChIKey=ZWGCULJAABCIOL-GFCCVEGCSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 50537733 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Phosphoinositide 3-Kinase (PI3K), delta
(Homo sapiens (Human)) | BDBM50537733
(CHEMBL4639546)Show SMILES CCC(=O)N1CCN(C[C@H]1C)c1nc(ncc1C#N)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H21N7O/c1-4-15(25)24-6-5-23(10-12(24)2)17-13(7-18)8-19-16(21-17)14-9-20-22(3)11-14/h8-9,11-12H,4-6,10H2,1-3H3/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 263 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of recombinant human full-length N-terminal GST-tagged p110delta/untagged full-length p85alpha expressed in baculovirus infected Sf21 cell... |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50537733
(CHEMBL4639546)Show SMILES CCC(=O)N1CCN(C[C@H]1C)c1nc(ncc1C#N)-c1cnn(C)c1 |r| Show InChI InChI=1S/C17H21N7O/c1-4-15(25)24-6-5-23(10-12(24)2)17-13(7-18)8-19-16(21-17)14-9-20-22(3)11-14/h8-9,11-12H,4-6,10H2,1-3H3/t12-/m1/s1 | PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 2.32E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co.
Curated by ChEMBL
| Assay Description
Inhibition of the fibroblast growth factor receptor (FGFR1) |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
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