BDBM50539199 CHEMBL4637249

SMILES: Cc1cc(C)c(cc1NC(=O)c1ccc(OCc2ccccn2)cc1)-c1cccc(N)n1

InChI Key: InChIKey=JDUTVKVDOQGKTH-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50539199   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Smoothened homolog (Mus musculus)	BDBM50539199 (CHEMBL4637249) Show SMILES Cc1cc(C)c(cc1NC(=O)c1ccc(OCc2ccccn2)cc1)-c1cccc(N)n1 Show InChI InChI=1S/C26H24N4O2/c1-17-14-18(2)24(15-22(17)23-7-5-8-25(27)29-23)30-26(31)19-9-11-21(12-10-19)32-16-20-6-3-4-13-28-20/h3-15H,16H2,1-2H3,(H2,27,29)(H,30,31)	PDB KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	1.70	n/a	n/a	n/a	n/a
AstraZeneca Curated by ChEMBL					Assay Description Inhibition of SMO-mediated Hedgehog signaling pathway in mouse C3H10T1/2 cells assessed as reduction in sonic hedgehog-induced osteoblast differentia...				Bioorg Med Chem 28: (2020)
					More data for this Ligand-Target Pair