BDBM50541320 CHEMBL4633783

SMILES: CCCCc1nc(=O)c(Cc2ccc(OC)cc2)c(O)n1-c1c(OC)cccc1OC

InChI Key: InChIKey=COQJEZJXUKTIIN-UHFFFAOYSA-N

Data: 1 EC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50541320   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Homo sapiens (Human))	BDBM50541320 (CHEMBL4633783) Show SMILES CCCCc1nc(=O)c(Cc2ccc(OC)cc2)c(O)n1-c1c(OC)cccc1OC |(23.06,-50.84,;24.39,-51.6,;25.73,-50.83,;27.06,-51.6,;28.39,-50.83,;28.4,-49.28,;29.73,-48.51,;29.73,-46.97,;31.06,-49.28,;32.4,-48.51,;33.73,-49.28,;33.73,-50.82,;35.06,-51.59,;36.39,-50.82,;37.73,-51.59,;39.06,-50.82,;36.39,-49.28,;35.06,-48.51,;31.06,-50.82,;32.4,-51.59,;29.73,-51.59,;29.73,-53.12,;28.4,-53.89,;27.07,-53.12,;25.73,-53.89,;28.4,-55.44,;29.73,-56.21,;31.07,-55.44,;31.07,-53.88,;32.4,-53.11,;33.73,-53.87,)| Show InChI InChI=1S/C24H28N2O5/c1-5-6-10-21-25-23(27)18(15-16-11-13-17(29-2)14-12-16)24(28)26(21)22-19(30-3)8-7-9-20(22)31-4/h7-9,11-14,28H,5-6,10,15H2,1-4H3	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	n/a	n/a	13	n/a	n/a	n/a	n/a
Bristol-Myers Squibb Research and Development Curated by ChEMBL					Assay Description Agonist activity at human APJ expressed in HEK293 cells assessed as inhibition of forskolin-stimulated cAMP production				Bioorg Med Chem Lett 30: (2020)
					More data for this Ligand-Target Pair