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BDBM50542859 CHEMBL4637810

SMILES: CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O

InChI Key: InChIKey=SADYRRFJQXPSEH-XSDIEEQYSA-N

Data: 2 KI  4 EC50

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50542859   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Neuropeptide Y receptor type 4


(Homo sapiens (Human))
BDBM50542859
PNG
(CHEMBL4637810)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21+/m0/s1
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93n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ measured after 90 mins by scintillation counting ...


J Med Chem 63: 8198-8215 (2020)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))
BDBM50542859
PNG
(CHEMBL4637810)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21+/m0/s1
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93n/an/an/an/an/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Displacement of [3H]UR-KK200 from human Y4 receptor expressed in CHO cells co-expressing Gqi5-mtAEQ measured after 90 mins by scintillation counting ...


J Med Chem 63: 8198-8215 (2020)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))
BDBM50542859
PNG
(CHEMBL4637810)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21+/m0/s1
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n/an/an/an/a<3.16E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...


J Med Chem 63: 8198-8215 (2020)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))
BDBM50542859
PNG
(CHEMBL4637810)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21+/m0/s1
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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...


J Med Chem 63: 8198-8215 (2020)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))
BDBM50542859
PNG
(CHEMBL4637810)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21+/m0/s1
PDB

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n/an/an/an/a>3.00E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB2 assessed as induction of beta-arrestin2 recruitment measured for 40 mins...


J Med Chem 63: 8198-8215 (2020)

More data for this
Ligand-Target Pair
Neuropeptide Y receptor type 4


(Homo sapiens (Human))
BDBM50542859
PNG
(CHEMBL4637810)
Show SMILES CC(C)C[C@@H](NC(=O)[C@@H](N)CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O |r|
Show InChI InChI=1S/C27H47N11O5/c1-15(2)13-21(38-23(41)18(28)5-3-11-34-26(30)31)25(43)36-19(6-4-12-35-27(32)33)24(42)37-20(22(29)40)14-16-7-9-17(39)10-8-16/h7-10,15,18-21,39H,3-6,11-14,28H2,1-2H3,(H2,29,40)(H,36,43)(H,37,42)(H,38,41)(H4,30,31,34)(H4,32,33,35)/t18-,19-,20-,21+/m0/s1
PDB

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PC sid
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n/an/an/an/a<3.16E+4n/an/an/an/a



University of Regensburg

Curated by ChEMBL


Assay Description
Agonist activity at human Y4R expressed in HEK293T cells co-expressing ARRB1 assessed as induction of beta-arrestin1 recruitment measured for 40 mins...


J Med Chem 63: 8198-8215 (2020)

More data for this
Ligand-Target Pair