null
SMILES: Cc1cc(cnc1OCC12CCC(N)(CC1)CC2)-c1ccnc2[nH]ncc12
InChI Key: InChIKey=DWTASGLRYAARGP-UHFFFAOYSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543137 (CHEMBL4634860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 68 | n/a | n/a | n/a | n/a | n/a | n/a |
Genomics Institute of the Novartis Research Foundation Curated by ChEMBL | Assay Description Displacement of 2-((1E,3E,5E)-5-(3,3-Dimethyl-1-(6-((4-(((3-methyl-5-(1H-pyrazolo[3,4-b]pyridin-4-yl)pyridin-2-yl)oxy)methyl)bicyclo[2.2.2]octan-1-yl... | J Med Chem 63: 8276-8295 (2020) Article DOI: 10.1021/acs.jmedchem.0c00130 BindingDB Entry DOI: 10.7270/Q2D22269 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Mus musculus) | BDBM50543137 (CHEMBL4634860) | Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in mouse splenocytes assessed as inhibition of ssRNA40-induced IL6 production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Homo sapiens (Human)) | BDBM50543137 (CHEMBL4634860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR9 in human PBMC assessed as inhibition of ODN2216-induced IFNalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 7 (Homo sapiens (Human)) | BDBM50543137 (CHEMBL4634860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR7 in human PBMC assessed as inhibition of ssRNA40-induced IFNalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 8 (Homo sapiens (Human)) | BDBM50543137 (CHEMBL4634860) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | <1 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR8 in human THP-1 cells assessed as inhibition of resiquimod-induced TNFalpha production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Toll-like receptor 9 (Mus musculus) | BDBM50543137 (CHEMBL4634860) | PDB Reactome pathway KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.20E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at TLR9 in mouse splenocytes assessed as inhibition of CpG1585-induced IL6 production | Citation and Details Article DOI: 10.1016/j.bmcl.2020.127366 BindingDB Entry DOI: 10.7270/Q2T43XS2 | |||||||||||
More data for this Ligand-Target Pair |