BDBM50543291 CHEMBL4644751
SMILES: C[C@H](C(=O)Nc1ccc(F)cc1)C12CC(C1)(C2)NC(=O)c1ccc(F)c(F)c1
InChI Key: InChIKey=QXQPETGZKGQABI-BQXHSLBWSA-N
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
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Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50543291 (CHEMBL4644751) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 1.90 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Inc. Curated by ChEMBL | Assay Description Inhibition of IDO1 in IFN-gamma stimulated human HeLa cells using L-tryptophan as substrate incubated for 48 hrs by fluorescence assay | ACS Med Chem Lett 11: 1548-1554 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Indoleamine 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50543291 (CHEMBL4644751) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 36 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Inc. Curated by ChEMBL | Assay Description Inhibition of IDO1 in human whole blood stimulated with IFNgamma/LPS using L-tryptophan/kynurenine as substrate incubated for 15 mins prior to IFNgam... | ACS Med Chem Lett 11: 1548-1554 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Pregnane X receptor (Homo sapiens (Human)) | BDBM50543291 (CHEMBL4644751) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | n/a | n/a | >3.00E+4 | n/a | n/a | n/a | n/a |
Merck & Co. Inc. Curated by ChEMBL | Assay Description Activation of PXR (unknown origin) | ACS Med Chem Lett 11: 1548-1554 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 4B1 (Homo sapiens) | BDBM50543291 (CHEMBL4644751) | PDB MMDB UniProtKB/SwissProt B.MOAD DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Inc. Curated by ChEMBL | Assay Description Inhibition of CYP450 (unknown origin) | ACS Med Chem Lett 11: 1548-1554 (2020) | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Tryptophan 2,3-dioxygenase (Homo sapiens (Human)) | BDBM50543291 (CHEMBL4644751) | PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
Merck & Co. Inc. Curated by ChEMBL | Assay Description Inhibition of TDO in human SW48 cells using L-tryptophan as substrate incubated for 48 hrs by fluorescent microplate reader assay | ACS Med Chem Lett 11: 1548-1554 (2020) | |||||||||||
More data for this Ligand-Target Pair |