BDBM50544510 CHEMBL4633626

SMILES: COC(=O)[C@@H]1Cc2c(CN1C(=O)CCN)[nH]c1ccccc21

InChI Key: InChIKey=DVHRYJBISMNEEB-AWEZNQCLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50544510   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50544510 (CHEMBL4633626) Show SMILES COC(=O)[C@@H]1Cc2c(CN1C(=O)CCN)[nH]c1ccccc21 |r| Show InChI InChI=1S/C16H19N3O3/c1-22-16(21)14-8-11-10-4-2-3-5-12(10)18-13(11)9-19(14)15(20)6-7-17/h2-5,14,18H,6-9,17H2,1H3/t14-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...				J Med Chem 63: 9672-9694 (2020)
					More data for this Ligand-Target Pair