BDBM50544514 CHEMBL4644123

SMILES: [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](CC(C)C)N1C(=O)[C@H](Cc1ccccc1)NC2=O

InChI Key: InChIKey=MSJBTEJXCBLQIY-BDTNDASRSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50544514   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50544514 (CHEMBL4644123) Show SMILES [H][C@@]12Cc3c([nH]c4ccccc34)[C@@H](CC(C)C)N1C(=O)[C@H](Cc1ccccc1)NC2=O |r| Show InChI InChI=1S/C25H27N3O2/c1-15(2)12-21-23-18(17-10-6-7-11-19(17)26-23)14-22-24(29)27-20(25(30)28(21)22)13-16-8-4-3-5-9-16/h3-11,15,20-22,26H,12-14H2,1-2H3,(H,27,29)/t20-,21+,22-/m0/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	4.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...				J Med Chem 63: 9672-9694 (2020)
					More data for this Ligand-Target Pair