BDBM50544528 CHEMBL4637481

SMILES: [H][C@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(CCCN)C2=O)c1ccc(F)cc1

InChI Key: InChIKey=IBEPCZMPULYCBG-QUCCMNQESA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50544528   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat))	BDBM50544528 (CHEMBL4637481) Show SMILES [H][C@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(CCCN)C2=O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C22H21FN4O2/c23-14-8-6-13(7-9-14)20-19-16(15-4-1-2-5-17(15)25-19)12-18-21(28)26(11-3-10-24)22(29)27(18)20/h1-2,4-9,18,20,25H,3,10-12,24H2/t18-,20+/m1/s1	UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	PubMed	n/a	n/a	2.72E+4	n/a	n/a	n/a	n/a	n/a	n/a
University of Salerno Curated by ChEMBL					Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b...				J Med Chem 63: 9672-9694 (2020)
					More data for this Ligand-Target Pair