BDBM50544530 CHEMBL4647182
SMILES: [H][C@]12Cc3c([nH]c4ccccc34)[C@@H](N1C(=O)N(C2=O)c1cccc(c1)C(F)(F)F)c1ccc(F)cc1
InChI Key: InChIKey=BKIVSJZNZNFDNY-GGAORHGYSA-N
Data: 1 IC50
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Transient receptor potential M8 protein (TRPM8) (Rattus norvegicus (Rat)) | BDBM50544530 (CHEMBL4647182) | UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | PubMed | n/a | n/a | 7.80E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
University of Salerno Curated by ChEMBL | Assay Description Antagonist activity at rat TRPM8 expressed in HEK293 cells assessed as inhibition of menthol-induced calcium flux preincubated for 60 mins followed b... | J Med Chem 63: 9672-9694 (2020) | |||||||||||
More data for this Ligand-Target Pair |