null

SMILES: COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1

InChI Key: InChIKey=QZSVFPPTVLGYBT-UHFFFAOYSA-N

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 19 hits for monomerid = 50544630   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of glutamate-induced intracellu...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.00E+4	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization i...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	140	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of 5HT-induced intracellular Ca...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	138	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of 5HT-induced intracellular Ca...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization inc...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	309	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization inc...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]-ketanserin from human HT2A receptor expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting method				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	79	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]-ketanserin from human HT2A receptor expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting method				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	70	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting meth...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	72	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell membranes incubated for 2 hrs by scintillation counting meth...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	120	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell co-expressing Gqo5 membranes incubated for 2 hrs by scintill...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	117	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Displacement of [3H]-ketanserin from human 5HT2A/mGlu2 receptor expressed in HEK293 cell co-expressing Gqo5 membranes incubated for 2 hrs by scintill...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization incubat...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	1.20E+3	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Agonist activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilization incubat...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	320	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Positive modulator activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilizat...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	324	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Positive modulator activity at human mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as increase in intracellular Ca2+ mobilizat...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	300	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	302	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A receptor expressed in HEK293 cells assessed as inhibition of 5HT-induced intracellular Ca2+ mobilization incubated...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair
5-hydroxytryptamine receptor 2A/Metabotropic glutamate receptor 2 (Homo sapiens (Human))	BDBM50544630 (CHEMBL4641860) Show SMILES COc1c(OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOc2ccc(cc2)C2CCN(CC2)c2ccn3c(CC4CC4)nnc3c2Cl)cccc1C(=O)C1CCN(CCc2ccc(F)cc2)CC1 Show InChI InChI=1S/C62H85ClFN5O13/c1-71-61-55(60(70)52-16-22-67(23-17-52)21-15-48-7-11-53(64)12-8-48)3-2-4-57(61)82-46-44-80-42-40-78-38-36-76-34-32-74-30-28-72-27-29-73-31-33-75-35-37-77-39-41-79-43-45-81-54-13-9-50(10-14-54)51-18-24-68(25-19-51)56-20-26-69-58(47-49-5-6-49)65-66-62(69)59(56)63/h2-4,7-14,20,26,49,51-52H,5-6,15-19,21-25,27-47H2,1H3	PDB UniProtKB/SwissProt antibodypedia antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.18E+3	n/a	n/a	n/a	n/a	n/a	n/a
University of Copenhagen Curated by ChEMBL					Assay Description Antagonist activity at human 5HT2A/mGlu2 receptor expressed in HEK293 cells co-expressing Gqo5 assessed as inhibition of glutamate-induced intracellu...				J Med Chem 63: 9928-9949 (2020) Article DOI: 10.1021/acs.jmedchem.0c01058 BindingDB Entry DOI: 10.7270/Q2ZC86GW
					More data for this Ligand-Target Pair