Found 5 hits for monomerid = 50544728 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544728
(CHEMBL4641474)Show SMILES CCC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:8.8,(51.91,-8.05,;50.58,-8.82,;49.24,-8.05,;49.24,-6.51,;47.91,-8.83,;46.57,-8.06,;45.24,-8.83,;45.24,-10.37,;43.91,-8.06,;43.9,-6.52,;45.24,-5.75,;45.23,-4.21,;46.57,-3.44,;46.57,-1.91,;45.24,-1.14,;43.9,-1.91,;43.9,-3.45,;42.57,-8.84,;41.24,-8.07,;41.24,-6.53,;39.91,-8.84,;38.5,-8.22,;37.47,-9.36,;35.94,-9.21,;35.31,-7.8,;36.21,-6.56,;35.59,-5.15,;33.78,-7.64,;32.87,-8.89,;33.49,-10.3,;35.03,-10.46,;35.65,-11.87,;34.75,-13.12,;38.24,-10.69,;37.63,-12.1,;38.54,-13.34,;37.92,-14.75,;40.07,-13.17,;39.75,-10.37,)| Show InChI InChI=1S/C30H38N4O5/c1-6-22(35)18-31-29(36)23(16-15-21-11-8-7-9-12-21)32-30(37)24-17-25(34(33-24)19-20(2)3)28-26(38-4)13-10-14-27(28)39-5/h7-14,17,20,23H,6,15-16,18-19H2,1-5H3,(H,31,36)(H,32,37)/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| 571 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Displacement of [125I]-apelin-13 from human APJ receptor stably expressed in CHOK1 cell membrane measured after 2 hrs by topcount scintillation count... |
Bioorg Med Chem 28: (2020)
|
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544728
(CHEMBL4641474)Show SMILES CCC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:8.8,(51.91,-8.05,;50.58,-8.82,;49.24,-8.05,;49.24,-6.51,;47.91,-8.83,;46.57,-8.06,;45.24,-8.83,;45.24,-10.37,;43.91,-8.06,;43.9,-6.52,;45.24,-5.75,;45.23,-4.21,;46.57,-3.44,;46.57,-1.91,;45.24,-1.14,;43.9,-1.91,;43.9,-3.45,;42.57,-8.84,;41.24,-8.07,;41.24,-6.53,;39.91,-8.84,;38.5,-8.22,;37.47,-9.36,;35.94,-9.21,;35.31,-7.8,;36.21,-6.56,;35.59,-5.15,;33.78,-7.64,;32.87,-8.89,;33.49,-10.3,;35.03,-10.46,;35.65,-11.87,;34.75,-13.12,;38.24,-10.69,;37.63,-12.1,;38.54,-13.34,;37.92,-14.75,;40.07,-13.17,;39.75,-10.37,)| Show InChI InChI=1S/C30H38N4O5/c1-6-22(35)18-31-29(36)23(16-15-21-11-8-7-9-12-21)32-30(37)24-17-25(34(33-24)19-20(2)3)28-26(38-4)13-10-14-27(28)39-5/h7-14,17,20,23H,6,15-16,18-19H2,1-5H3,(H,31,36)(H,32,37)/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | n/a | n/a | 162 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at human APJ receptor stably expressed in CHO cells co-expressing Galphaq16 assessed as increase in intracellular calcium mobilizati... |
Bioorg Med Chem 28: (2020)
|
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544728
(CHEMBL4641474)Show SMILES CCC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:8.8,(51.91,-8.05,;50.58,-8.82,;49.24,-8.05,;49.24,-6.51,;47.91,-8.83,;46.57,-8.06,;45.24,-8.83,;45.24,-10.37,;43.91,-8.06,;43.9,-6.52,;45.24,-5.75,;45.23,-4.21,;46.57,-3.44,;46.57,-1.91,;45.24,-1.14,;43.9,-1.91,;43.9,-3.45,;42.57,-8.84,;41.24,-8.07,;41.24,-6.53,;39.91,-8.84,;38.5,-8.22,;37.47,-9.36,;35.94,-9.21,;35.31,-7.8,;36.21,-6.56,;35.59,-5.15,;33.78,-7.64,;32.87,-8.89,;33.49,-10.3,;35.03,-10.46,;35.65,-11.87,;34.75,-13.12,;38.24,-10.69,;37.63,-12.1,;38.54,-13.34,;37.92,-14.75,;40.07,-13.17,;39.75,-10.37,)| Show InChI InChI=1S/C30H38N4O5/c1-6-22(35)18-31-29(36)23(16-15-21-11-8-7-9-12-21)32-30(37)24-17-25(34(33-24)19-20(2)3)28-26(38-4)13-10-14-27(28)39-5/h7-14,17,20,23H,6,15-16,18-19H2,1-5H3,(H,31,36)(H,32,37)/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | n/a | n/a | 8.67E+3 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at human APJ receptor stably expressed in CHOK1 cells assessed as induction of beta-arrestin 2 recruitment incubated for 90 mins by ... |
Bioorg Med Chem 28: (2020)
|
More data for this Ligand-Target Pair | |
Angiotensin II receptor
(Homo sapiens (Human)) | BDBM50544728
(CHEMBL4641474)Show SMILES CCC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:8.8,(51.91,-8.05,;50.58,-8.82,;49.24,-8.05,;49.24,-6.51,;47.91,-8.83,;46.57,-8.06,;45.24,-8.83,;45.24,-10.37,;43.91,-8.06,;43.9,-6.52,;45.24,-5.75,;45.23,-4.21,;46.57,-3.44,;46.57,-1.91,;45.24,-1.14,;43.9,-1.91,;43.9,-3.45,;42.57,-8.84,;41.24,-8.07,;41.24,-6.53,;39.91,-8.84,;38.5,-8.22,;37.47,-9.36,;35.94,-9.21,;35.31,-7.8,;36.21,-6.56,;35.59,-5.15,;33.78,-7.64,;32.87,-8.89,;33.49,-10.3,;35.03,-10.46,;35.65,-11.87,;34.75,-13.12,;38.24,-10.69,;37.63,-12.1,;38.54,-13.34,;37.92,-14.75,;40.07,-13.17,;39.75,-10.37,)| Show InChI InChI=1S/C30H38N4O5/c1-6-22(35)18-31-29(36)23(16-15-21-11-8-7-9-12-21)32-30(37)24-17-25(34(33-24)19-20(2)3)28-26(38-4)13-10-14-27(28)39-5/h7-14,17,20,23H,6,15-16,18-19H2,1-5H3,(H,31,36)(H,32,37)/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt UniProtKB/TrEMBL
DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at human AGTR1 stably expressed in CHO cells assessed as increase in intracellular calcium mobilization measured at 1 sec intervals ... |
Bioorg Med Chem 28: (2020)
|
More data for this Ligand-Target Pair | |
Apelin receptor
(Homo sapiens (Human)) | BDBM50544728
(CHEMBL4641474)Show SMILES CCC(=O)CNC(=O)[C@H](CCc1ccccc1)NC(=O)c1cc(-c2c(OC)cccc2OC)n(CC(C)C)n1 |r,wU:8.8,(51.91,-8.05,;50.58,-8.82,;49.24,-8.05,;49.24,-6.51,;47.91,-8.83,;46.57,-8.06,;45.24,-8.83,;45.24,-10.37,;43.91,-8.06,;43.9,-6.52,;45.24,-5.75,;45.23,-4.21,;46.57,-3.44,;46.57,-1.91,;45.24,-1.14,;43.9,-1.91,;43.9,-3.45,;42.57,-8.84,;41.24,-8.07,;41.24,-6.53,;39.91,-8.84,;38.5,-8.22,;37.47,-9.36,;35.94,-9.21,;35.31,-7.8,;36.21,-6.56,;35.59,-5.15,;33.78,-7.64,;32.87,-8.89,;33.49,-10.3,;35.03,-10.46,;35.65,-11.87,;34.75,-13.12,;38.24,-10.69,;37.63,-12.1,;38.54,-13.34,;37.92,-14.75,;40.07,-13.17,;39.75,-10.37,)| Show InChI InChI=1S/C30H38N4O5/c1-6-22(35)18-31-29(36)23(16-15-21-11-8-7-9-12-21)32-30(37)24-17-25(34(33-24)19-20(2)3)28-26(38-4)13-10-14-27(28)39-5/h7-14,17,20,23H,6,15-16,18-19H2,1-5H3,(H,31,36)(H,32,37)/t23-/m0/s1 | PDB
Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| PubMed
| n/a | n/a | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a |
RTI International
Curated by ChEMBL
| Assay Description Agonist activity at human APJ receptor stably expressed in CHO cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 30 ... |
Bioorg Med Chem 28: (2020)
|
More data for this Ligand-Target Pair | |