Found 5 hits for monomerid = 50544786 Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kcal/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50544786
(CHEMBL4637587)Show SMILES [H][C@@]12CN(C(=O)[C@]1(C#N)C1CC1)c1ccnc(Nc3cccc(CNC(=O)COC2)n3)c1 |r| Show InChI InChI=1S/C22H22N6O3/c23-13-22(14-4-5-14)15-10-28(21(22)30)17-6-7-24-19(8-17)27-18-3-1-2-16(26-18)9-25-20(29)12-31-11-15/h1-3,6-8,14-15H,4-5,9-12H2,(H,25,29)(H,24,26,27)/t15-,22+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet 
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Inhibition of TYK2 (unknown origin) |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK1
(Homo sapiens (Human)) | BDBM50544786
(CHEMBL4637587)Show SMILES [H][C@@]12CN(C(=O)[C@]1(C#N)C1CC1)c1ccnc(Nc3cccc(CNC(=O)COC2)n3)c1 |r| Show InChI InChI=1S/C22H22N6O3/c23-13-22(14-4-5-14)15-10-28(21(22)30)17-6-7-24-19(8-17)27-18-3-1-2-16(26-18)9-25-20(29)12-31-11-15/h1-3,6-8,14-15H,4-5,9-12H2,(H,25,29)(H,24,26,27)/t15-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 3.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Inhibition of JAK1 (unknown origin) |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
Non-receptor tyrosine-protein kinase TYK2
(Homo sapiens (Human)) | BDBM50544786
(CHEMBL4637587)Show SMILES [H][C@@]12CN(C(=O)[C@]1(C#N)C1CC1)c1ccnc(Nc3cccc(CNC(=O)COC2)n3)c1 |r| Show InChI InChI=1S/C22H22N6O3/c23-13-22(14-4-5-14)15-10-28(21(22)30)17-6-7-24-19(8-17)27-18-3-1-2-16(26-18)9-25-20(29)12-31-11-15/h1-3,6-8,14-15H,4-5,9-12H2,(H,25,29)(H,24,26,27)/t15-,22+/m0/s1 | PDB
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.30E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Inhibition of TYK2 in human Jurkat cells by luciferase reporter gene assay |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK3
(Homo sapiens (Human)) | BDBM50544786
(CHEMBL4637587)Show SMILES [H][C@@]12CN(C(=O)[C@]1(C#N)C1CC1)c1ccnc(Nc3cccc(CNC(=O)COC2)n3)c1 |r| Show InChI InChI=1S/C22H22N6O3/c23-13-22(14-4-5-14)15-10-28(21(22)30)17-6-7-24-19(8-17)27-18-3-1-2-16(26-18)9-25-20(29)12-31-11-15/h1-3,6-8,14-15H,4-5,9-12H2,(H,25,29)(H,24,26,27)/t15-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
UniProtKB/TrEMBL
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.90E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Inhibition of JAK3 (unknown origin) |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
Tyrosine-protein kinase JAK2
(Homo sapiens (Human)) | BDBM50544786
(CHEMBL4637587)Show SMILES [H][C@@]12CN(C(=O)[C@]1(C#N)C1CC1)c1ccnc(Nc3cccc(CNC(=O)COC2)n3)c1 |r| Show InChI InChI=1S/C22H22N6O3/c23-13-22(14-4-5-14)15-10-28(21(22)30)17-6-7-24-19(8-17)27-18-3-1-2-16(26-18)9-25-20(29)12-31-11-15/h1-3,6-8,14-15H,4-5,9-12H2,(H,25,29)(H,24,26,27)/t15-,22+/m0/s1 | PDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| PubMed
| n/a | n/a | 1.00E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
Takeda Pharmaceutical Company Limited
Curated by ChEMBL
| Assay Description
Inhibition of JAK2 (unknown origin) |
Bioorg Med Chem Lett 30: (2020)
|
More data for this
Ligand-Target Pair | |
Search and Browse
