BindingDB PrimarySearch_ki

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Enter Data

null

SMILES: Cl.Cl.COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1c1ncc([nH]1)-c1ccc(cc1)C#CC#Cc1cnc([nH]1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)c1ccccc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50547648
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Nonstructural protein 5A (Hepatitis C virus)	BDBM50547648 (CHEMBL4800349) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.40	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of HCV genotype 5a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115716 BindingDB Entry DOI: 10.7270/Q29K4FTX
TBA					More data for this Ligand-Target Pair
Nonstructural protein 5A (Hepatitis C virus)	BDBM50547648 (CHEMBL4800349) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	10.7	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of HCV genotype 3a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115716 BindingDB Entry DOI: 10.7270/Q29K4FTX
TBA					More data for this Ligand-Target Pair
Nonstructural protein 5A (Hepatitis C virus)	BDBM50547648 (CHEMBL4800349) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.431	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of HCV genotype 2a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115716 BindingDB Entry DOI: 10.7270/Q29K4FTX
TBA					More data for this Ligand-Target Pair
Nonstructural protein 5A (Hepatitis C virus)	BDBM50547648 (CHEMBL4800349) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.758	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of HCV genotype 1a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115716 BindingDB Entry DOI: 10.7270/Q29K4FTX
TBA					More data for this Ligand-Target Pair
Nonstructural protein 5A (Hepatitis C virus)	BDBM50547648 (CHEMBL4800349) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.0120	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of HCV genotype 1b NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by Celltiter Glo a...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115716 BindingDB Entry DOI: 10.7270/Q29K4FTX
TBA					More data for this Ligand-Target Pair
Nonstructural protein 5A (Hepatitis C virus)	BDBM50547648 (CHEMBL4800349) Show SMILES Show InChI	PDB UniProtKB/TrEMBL GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	0.423	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of HCV genotype 4a NS5A infected in Huh7 cells assessed as reduction in viral replication incubated 3 days and measured by bright Glo-luci...				Citation and Details Article DOI: 10.1016/j.bmc.2020.115716 BindingDB Entry DOI: 10.7270/Q29K4FTX
TBA					More data for this Ligand-Target Pair