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SMILES: Cc1nc2ncnn2c(N)c1Cc1ccc(Br)c(OC(F)F)n1

InChI Key:

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50548076   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Ghrelin O-acyltransferase


(Homo sapiens (Human))		BDBM50548076
PNG
(CHEMBL4781133 | US11583532, Example 5.1)
Show SMILES Cc1nc2ncnn2c(N)c1Cc1ccc(Br)c(OC(F)F)n1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
US Patent
n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
Methods: Cells are plated with a density of 5000 cells/well in 384-well poly-D-lysin plates and incubated for 1 day at 37° C., 5% CO2 in DMEM medium,...

Citation and Details

BindingDB Entry DOI: 10.7270/Q24171ZT
More data for this
Ligand-Target Pair
Ghrelin O-acyltransferase


(Homo sapiens (Human))		BDBM50548076
PNG
(CHEMBL4781133 | US11583532, Example 5.1)
Show SMILES Cc1nc2ncnn2c(N)c1Cc1ccc(Br)c(OC(F)F)n1
UniProtKB/SwissProt

GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 0.130n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human GOAT expressed in HEK293 cells harboring -preproghrelin in presence of Octanoate-BSA incubated for 5 hr by ELISA

Citation and Details

Article DOI: 10.1039/d0md00210k
BindingDB Entry DOI: 10.7270/Q2KS6W53
More data for this
Ligand-Target Pair