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null

SMILES: COc1cc2CCn3c(cc(OCCOc4ccccn4)nc3=O)-c2cc1OC

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50548412
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
G-protein coupled receptor 84 (Homo sapiens (Human))	BDBM50548412 (CHEMBL4776061) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	8	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00272 BindingDB Entry DOI: 10.7270/Q2V40ZT3
TBA					More data for this Ligand-Target Pair
G-protein coupled receptor 84 (Homo sapiens (Human))	BDBM50548412 (CHEMBL4776061) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	11	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at recombinant human GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduction i...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00272 BindingDB Entry DOI: 10.7270/Q2V40ZT3
TBA					More data for this Ligand-Target Pair
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (Homo sapiens (Human))	BDBM50548412 (CHEMBL4776061) Show SMILES Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	586	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human PDE4A overexpressed in HEK293 cells assessed as reduction in cAMP hydrolysis by HTRF based immunoassay				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00272 BindingDB Entry DOI: 10.7270/Q2V40ZT3
TBA					More data for this Ligand-Target Pair
G-protein coupled receptor 84 (Mus musculus)	BDBM50548412 (CHEMBL4776061) Show SMILES Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	636	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inverse agonist activity at recombinant mouse GPR84 receptor expressed in HEK293 cells co-expressing GNAO1 transcription variant 1 assessed as reduct...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c00272 BindingDB Entry DOI: 10.7270/Q2V40ZT3
TBA					More data for this Ligand-Target Pair