null

SMILES: OC1(CCC2(CC1)C(C1CC1)N(c1ccc(NC(=O)c3cccnc3)cc21)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50548466   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50548466 (CHEMBL4757424) Show SMILES OC1(CCC2(CC1)C(C1CC1)N(c1ccc(NC(=O)c3cccnc3)cc21)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F |(57.14,-3.38,;56.05,-4.48,;57.14,-5.57,;56.75,-7.05,;55.26,-7.46,;54.16,-6.38,;54.56,-4.89,;56.19,-8.7,;57.73,-8.68,;59.07,-9.43,;59.05,-7.89,;55.29,-9.96,;53.81,-9.5,;52.47,-10.28,;51.14,-9.51,;51.14,-7.98,;49.8,-7.21,;48.47,-7.99,;48.48,-9.53,;47.13,-7.22,;47.13,-5.69,;45.8,-4.92,;44.47,-5.7,;44.48,-7.25,;45.82,-8.01,;52.46,-7.2,;53.8,-7.96,;55.78,-11.42,;57.27,-11.01,;56.87,-12.5,;54.77,-12.58,;53.26,-12.28,;52.24,-13.44,;52.74,-14.9,;51.73,-16.06,;54.27,-15.19,;55.27,-14.03,;55.64,-2.99,;56.73,-1.89,;54.15,-2.59,;55.24,-1.49,)| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	228	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of buserelin-induced response preincubated for 20 mins fo...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9
					More data for this Ligand-Target Pair
Gonadotropin-releasing hormone receptor (Homo sapiens (Human))	BDBM50548466 (CHEMBL4757424) Show SMILES OC1(CCC2(CC1)C(C1CC1)N(c1ccc(NC(=O)c3cccnc3)cc21)S(=O)(=O)c1ccc(F)cc1)C(F)(F)F |(57.14,-3.38,;56.05,-4.48,;57.14,-5.57,;56.75,-7.05,;55.26,-7.46,;54.16,-6.38,;54.56,-4.89,;56.19,-8.7,;57.73,-8.68,;59.07,-9.43,;59.05,-7.89,;55.29,-9.96,;53.81,-9.5,;52.47,-10.28,;51.14,-9.51,;51.14,-7.98,;49.8,-7.21,;48.47,-7.99,;48.48,-9.53,;47.13,-7.22,;47.13,-5.69,;45.8,-4.92,;44.47,-5.7,;44.48,-7.25,;45.82,-8.01,;52.46,-7.2,;53.8,-7.96,;55.78,-11.42,;57.27,-11.01,;56.87,-12.5,;54.77,-12.58,;53.26,-12.28,;52.24,-13.44,;52.74,-14.9,;51.73,-16.06,;54.27,-15.19,;55.27,-14.03,;55.64,-2.99,;56.73,-1.89,;54.15,-2.59,;55.24,-1.49,)| Show InChI	PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	78	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followe...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9
					More data for this Ligand-Target Pair