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SMILES: CC1N(c2ccc(cc2C11CCNCC1)C(=O)NCc1ccccc1Cl)S(=O)(=O)c1ccc(F)cc1
InChI Key:
| Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50548473 (CHEMBL4740373) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet  | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followe... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50548473 (CHEMBL4740373) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 99 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followe... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50548473 (CHEMBL4740373) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of buserelin-induced response preincubated for 20 mins fo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50548473 (CHEMBL4740373) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.10E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ERG expressed in HEK293 cells assessed as reduction in channel inward tail current by whole cell voltage clamp assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50548473 (CHEMBL4740373) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at rat GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followed ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Rattus norvegicus) | BDBM50548473 (CHEMBL4740373) | KEGG UniProtKB/SwissProt GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 27 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at rat GnRH receptor expressed in CHO-K1 cells assessed as inhibition of LHRH-induced response preincubated for 20 mins followed ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
| Gonadotropin-releasing hormone receptor (Homo sapiens (Human)) | BDBM50548473 (CHEMBL4740373) | PDB KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 172 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Antagonist activity at human GnRH receptor expressed in CHO-K1 cells assessed as inhibition of buserelin-induced response preincubated for 20 mins fo... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01076 BindingDB Entry DOI: 10.7270/Q26D5XK9 | |||||||||||
| More data for this Ligand-Target Pair | |||||||||||||
