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SMILES: COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50550133   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Serine/threonine-protein kinase RIO2 (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Displacement of tracer K5 from N-terminal nanoluciferase-tagged RIOK2 (unknown origin) expressed in HEK293 cells measured after 2 hrs by NanoBRET ass...				Citation and Details Article DOI: 10.1039/d0md00292e BindingDB Entry DOI: 10.7270/Q2251NSH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 8 (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full length recombinant human MAPK8 using ATF2 as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintilla...				Citation and Details Article DOI: 10.1039/d0md00292e BindingDB Entry DOI: 10.7270/Q2251NSH
					More data for this Ligand-Target Pair
Mitogen-activated protein kinase 10 (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	5.10E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of full length recombinant human MAPK10 using peptide substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scintill...				Citation and Details Article DOI: 10.1039/d0md00292e BindingDB Entry DOI: 10.7270/Q2251NSH
					More data for this Ligand-Target Pair
Serine/threonine-protein kinase RIO2 (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.60E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA									Citation and Details Article DOI: 10.1021/acs.jmedchem.2c00271 BindingDB Entry DOI: 10.7270/Q2930Z8M
					More data for this Ligand-Target Pair
SNF-related serine/threonine-protein kinase (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human SNRK E97G/P116A mutant (1 to 505 residues) using KKLRRTLSFAEPG peptide as substrate incubated for 40 mins in presence...				Citation and Details Article DOI: 10.1039/d0md00292e BindingDB Entry DOI: 10.7270/Q2251NSH
					More data for this Ligand-Target Pair
Homeodomain-interacting protein kinase 1 (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	>1.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human HIPK1 (158 to 555 residues) using myelin ba as substrate incubated for 40 mins in presence of [gamma33P]ATP by radiometric scinti...				Citation and Details Article DOI: 10.1039/d0md00292e BindingDB Entry DOI: 10.7270/Q2251NSH
					More data for this Ligand-Target Pair
Glycogen synthase kinase-3 alpha (Homo sapiens (Human))	BDBM50550133 (CHEMBL4754518) Show SMILES COc1ccc2cc(ccc2c1)[C@H](C)C(=O)Nc1cc(C)ccn1 |r| Show InChI	PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.50E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human GSK3alpha S449A mutant (2 to end residues) using YRRAAVPPSPSLSR peptide as substrate incubated for 40 mins in presenc...				Citation and Details Article DOI: 10.1039/d0md00292e BindingDB Entry DOI: 10.7270/Q2251NSH
					More data for this Ligand-Target Pair