null
SMILES: COc1ccc(C[C@@H]2NC(=O)[C@@H](NC(=O)[C@@H]3CCCCC(=O)NCc4ccc(C[C@H](NC(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)CCSCc5cccc(CSCCNC(=O)[C@]6(C)CCCN6C2=O)c5)C(=O)N[C@@H](Cc2c[nH]c5ccc(F)cc25)C(=O)N3)cc4)[C@@H](C)O)cc1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Proprotein convertase subtilisin/kexin type 9 (Homo sapiens (Human)) | BDBM50554761![]() (CHEMBL4759482) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | 175 | n/a | n/a | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of AlexaFluor647-tagged cyclic peptide binding to avi-tagged-biotinylated human PCSK9 measured after 2 hrs by Lance Streptavidin Europium ... | Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01084 BindingDB Entry DOI: 10.7270/Q23N272N | |||||||||||
More data for this Ligand-Target Pair |