null

SMILES: Cc1ccc2n(Cc3cccc(c3C#N)C(F)(F)F)c(=O)n(C[C@H]3CC[C@@H](CC3)C(=O)Nc3ccncc3)c(=O)c2c1C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50557886   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50557886 (CHEMBL4786460) Show SMILES Cc1ccc2n(Cc3cccc(c3C#N)C(F)(F)F)c(=O)n(C[C@H]3CC[C@@H](CC3)C(=O)Nc3ccncc3)c(=O)c2c1C |r,wU:26.30,wD:23.23,(48.53,-30.7,;49.87,-31.47,;49.87,-33.01,;51.2,-33.78,;52.54,-33.02,;53.88,-33.78,;53.88,-35.32,;52.55,-36.1,;51.22,-35.33,;49.89,-36.1,;49.89,-37.64,;51.24,-38.41,;52.56,-37.63,;53.91,-38.39,;55.25,-39.16,;51.25,-39.95,;49.84,-40.65,;52.83,-40.08,;51.09,-41.39,;55.23,-33.01,;56.56,-33.77,;55.22,-31.45,;56.55,-30.68,;57.89,-31.44,;57.88,-32.99,;59.21,-33.75,;60.55,-32.99,;60.54,-31.44,;59.21,-30.67,;61.88,-33.76,;61.88,-35.3,;63.21,-32.99,;64.55,-33.76,;64.54,-35.3,;65.87,-36.07,;67.21,-35.3,;67.2,-33.75,;65.87,-32.99,;53.87,-30.67,;53.86,-29.13,;52.53,-31.46,;51.2,-30.7,;51.19,-29.16,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	100	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human TNKS2 incubated for 1 to 2 hrs by fluorescence polarization assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00160 BindingDB Entry DOI: 10.7270/Q2W099KF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50557886 (CHEMBL4786460) Show SMILES Cc1ccc2n(Cc3cccc(c3C#N)C(F)(F)F)c(=O)n(C[C@H]3CC[C@@H](CC3)C(=O)Nc3ccncc3)c(=O)c2c1C |r,wU:26.30,wD:23.23,(48.53,-30.7,;49.87,-31.47,;49.87,-33.01,;51.2,-33.78,;52.54,-33.02,;53.88,-33.78,;53.88,-35.32,;52.55,-36.1,;51.22,-35.33,;49.89,-36.1,;49.89,-37.64,;51.24,-38.41,;52.56,-37.63,;53.91,-38.39,;55.25,-39.16,;51.25,-39.95,;49.84,-40.65,;52.83,-40.08,;51.09,-41.39,;55.23,-33.01,;56.56,-33.77,;55.22,-31.45,;56.55,-30.68,;57.89,-31.44,;57.88,-32.99,;59.21,-33.75,;60.55,-32.99,;60.54,-31.44,;59.21,-30.67,;61.88,-33.76,;61.88,-35.3,;63.21,-32.99,;64.55,-33.76,;64.54,-35.3,;65.87,-36.07,;67.21,-35.3,;67.2,-33.75,;65.87,-32.99,;53.87,-30.67,;53.86,-29.13,;52.53,-31.46,;51.2,-30.7,;51.19,-29.16,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	6.30	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human TNKS1 incubated for 1 to 2 hrs by fluorescence polarization assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00160 BindingDB Entry DOI: 10.7270/Q2W099KF
					More data for this Ligand-Target Pair