null

SMILES: Cc1c(ccc2n(Cc3cccc(c3C#N)C(F)(F)F)c(=O)n(C[C@H]3CC[C@@H](CC3)C(=O)Nc3ccncc3)c(=O)c12)C(N)=O

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50557887   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Poly [ADP-ribose] polymerase tankyrase-2 (Homo sapiens (Human))	BDBM50557887 (CHEMBL4762657) Show SMILES Cc1c(ccc2n(Cc3cccc(c3C#N)C(F)(F)F)c(=O)n(C[C@H]3CC[C@@H](CC3)C(=O)Nc3ccncc3)c(=O)c12)C(N)=O |r,wU:27.31,wD:24.24,(6.24,-43.47,;6.25,-45.01,;4.92,-45.78,;4.92,-47.32,;6.25,-48.09,;7.59,-47.33,;8.93,-48.1,;8.94,-49.64,;7.61,-50.41,;6.27,-49.64,;4.94,-50.41,;4.95,-51.95,;6.29,-52.72,;7.62,-51.94,;8.96,-52.7,;10.3,-53.47,;6.3,-54.26,;4.89,-54.96,;7.89,-54.39,;6.14,-55.7,;10.28,-47.32,;11.61,-48.09,;10.27,-45.76,;11.6,-44.99,;12.94,-45.75,;12.93,-47.3,;14.26,-48.06,;15.6,-47.3,;15.6,-45.75,;14.26,-44.98,;16.93,-48.07,;16.93,-49.61,;18.27,-47.3,;19.6,-48.07,;19.59,-49.61,;20.93,-50.38,;22.26,-49.61,;22.26,-48.06,;20.92,-47.3,;8.92,-44.99,;8.92,-43.44,;7.58,-45.77,;3.59,-45.01,;3.59,-43.47,;2.25,-45.78,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	251	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human TNKS2 incubated for 1 to 2 hrs by fluorescence polarization assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00160 BindingDB Entry DOI: 10.7270/Q2W099KF
					More data for this Ligand-Target Pair
Poly [ADP-ribose] polymerase tankyrase-1 (Homo sapiens (Human))	BDBM50557887 (CHEMBL4762657) Show SMILES Cc1c(ccc2n(Cc3cccc(c3C#N)C(F)(F)F)c(=O)n(C[C@H]3CC[C@@H](CC3)C(=O)Nc3ccncc3)c(=O)c12)C(N)=O |r,wU:27.31,wD:24.24,(6.24,-43.47,;6.25,-45.01,;4.92,-45.78,;4.92,-47.32,;6.25,-48.09,;7.59,-47.33,;8.93,-48.1,;8.94,-49.64,;7.61,-50.41,;6.27,-49.64,;4.94,-50.41,;4.95,-51.95,;6.29,-52.72,;7.62,-51.94,;8.96,-52.7,;10.3,-53.47,;6.3,-54.26,;4.89,-54.96,;7.89,-54.39,;6.14,-55.7,;10.28,-47.32,;11.61,-48.09,;10.27,-45.76,;11.6,-44.99,;12.94,-45.75,;12.93,-47.3,;14.26,-48.06,;15.6,-47.3,;15.6,-45.75,;14.26,-44.98,;16.93,-48.07,;16.93,-49.61,;18.27,-47.3,;19.6,-48.07,;19.59,-49.61,;20.93,-50.38,;22.26,-49.61,;22.26,-48.06,;20.92,-47.3,;8.92,-44.99,;8.92,-43.44,;7.58,-45.77,;3.59,-45.01,;3.59,-43.47,;2.25,-45.78,)| Show InChI	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human TNKS1 incubated for 1 to 2 hrs by fluorescence polarization assay				Citation and Details Article DOI: 10.1021/acsmedchemlett.1c00160 BindingDB Entry DOI: 10.7270/Q2W099KF
					More data for this Ligand-Target Pair