null
SMILES: Cc1cc(ccn1)-c1ccc2OCCn3c(Oc4cccc(OC(F)(F)F)c4)nnc3-c2c1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Cytochrome P450 2C9 (Homo sapiens (Human)) | BDBM50558164![]() (CHEMBL4751613) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.43E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human liver microsomes CYP2C9 using diclofenac as substrate by MUX-MS/MS analysis | Citation and Details Article DOI: 10.1016/j.bmcl.2016.04.018 BindingDB Entry DOI: 10.7270/Q2HM5D44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 2D6 (Homo sapiens (Human)) | BDBM50558164![]() (CHEMBL4751613) | PDB UniProtKB/SwissProt GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 1.95E+3 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human liver microsomes CYP2D6 using dextromethorphan as substrate by MUX-MS/MS analysis | Citation and Details Article DOI: 10.1016/j.bmcl.2016.04.018 BindingDB Entry DOI: 10.7270/Q2HM5D44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Probable G-protein coupled receptor 142 (Homo sapiens (Human)) | BDBM50558164![]() (CHEMBL4751613) | KEGG UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 78 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Agonist activity at human GPR142 expressed in CHO cells measured for 3 mins by Fluo-4M dye based FLIPR assay | Citation and Details Article DOI: 10.1016/j.bmcl.2016.04.018 BindingDB Entry DOI: 10.7270/Q2HM5D44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Potassium voltage-gated channel subfamily H member 2 (Homo sapiens (Human)) | BDBM50558164![]() (CHEMBL4751613) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 693 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human ERG expressed in HEK293 cells assessed as reduction in S35-MK-0499 binding | Citation and Details Article DOI: 10.1016/j.bmcl.2016.04.018 BindingDB Entry DOI: 10.7270/Q2HM5D44 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Cytochrome P450 3A4 (Homo sapiens (Human)) | BDBM50558164![]() (CHEMBL4751613) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet ![]() | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >5.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of human liver microsomes CYP3A4 using testosterone as substrate by MUX-MS/MS analysis | Citation and Details Article DOI: 10.1016/j.bmcl.2016.04.018 BindingDB Entry DOI: 10.7270/Q2HM5D44 | |||||||||||
More data for this Ligand-Target Pair |