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Target
Sequence
Name
&
Ki
IC50
Kd
EC50
Rate constants
ΔG°
ΔH°
-TΔS°
pH (Enzymatic Assay)
pH (ITC)
Substrate or Competitor
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Ki
IC50
Kd
EC50
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null
SMILES:
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
InChI Key:
Find this compound or compounds like it in BindingDB or PDB:
Substructure
Similarity at least:
must be >=0.5
Exact match
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found
22
hits for monomerid = 50563052
Target/Host
(Institution)
Ligand
Target/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
k
off
s
-1
k
on
M
-1
s
-1
pH
Temp
°C
P2X purinoceptor 3
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
16
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human P2X3 receptor expressed in rat C6-BU-1 cells
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
Cytochrome P450 3A4
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP3A4 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 1
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human P2X1 receptor expressed in rat C6-BU-1 cells
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
P2X purinoceptor 2
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human P2X2 receptor expressed in rat C6-BU-1 cells
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
P2X purinoceptor 4
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human P2X4 receptor expressed in rat C6-BU-1 cells
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
P2X purinoceptor 7
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human P2X7 receptor expressed in HEK293 cells
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
Cytochrome P450 1A2
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP1A2 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
Cytochrome P450 2C9
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP2C9 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
Cytochrome P450 2C19
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP2C19 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
Cytochrome P450 2D6
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP2D6 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
Cytochrome P450 3A4
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP3A4 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair
P2X purinoceptor 3
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
16
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at P2X3 receptor (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 3
(RAT)
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
6.10
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at rat P2X3 receptor
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 1
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
Reactome pathway
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at P2X1 receptor (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 2
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at P2X2 receptor (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 4
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
KEGG
UniProtKB/SwissProt
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at P2X4 receptor (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 7
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
KEGG
UniProtKB/SwissProt
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>3.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at P2X7 receptor (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
Cytochrome P450 1A2
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP1A2 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
Cytochrome P450 2C9
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP2C9 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
Cytochrome P450 2C19
(Homo sapiens)
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP2C19 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
Cytochrome P450 2D6
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
>2.00E+4
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Inhibition of CYP2D6 (unknown origin)
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.128384
BindingDB Entry DOI:
10.7270/Q2S46WTX
More data for this
Ligand-Target Pair
P2X purinoceptor 2/3
(Homo sapiens (Human))
BDBM50563052
(CHEMBL4748113)
Show SMILES
CC(C)Oc1ccc(Nc2nc(=O)n(CCC(O)=O)c(=O)n2Cc2ccc(C)cc2)cc1Cl
Show InChI
PDB
MMDB
NCI pathway
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
antibodypedia
GoogleScholar
AffyNet
PC cid
PC sid
UniChem
Article
PubMed
n/a
n/a
2.93E+3
n/a
n/a
n/a
n/a
n/a
n/a
TBA
Assay Description
Antagonist activity at human P2X2/3 receptor
Citation and Details
Article DOI:
10.1016/j.bmcl.2021.127833
BindingDB Entry DOI:
10.7270/Q2V40ZXF
More data for this
Ligand-Target Pair