null

SMILES: CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(Cl)cc13)C2

InChI Key:

PDB links: 1 PDB ID matches this monomer.

Find this compound or compounds like it in BindingDB or PDB:

Substructure Similarity at least:  must be >=0.5 Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50563641   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Receptor-type tyrosine-protein kinase FLT3 (Homo sapiens (Human))	BDBM50563641 (CHEMBL4744243) Show SMILES CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(Cl)cc13)C2 |(43.22,-48.73,;41.68,-48.73,;40.91,-50.06,;41.68,-51.39,;39.37,-50.05,;38.47,-48.8,;37,-49.27,;37,-50.81,;38.46,-51.29,;38.92,-52.75,;40.46,-52.75,;39.69,-54.09,;37.9,-53.9,;35.75,-48.36,;35.76,-46.82,;34.3,-46.34,;33.39,-47.59,;34.29,-48.83,;33.81,-50.3,;32.3,-50.61,;31.28,-49.46,;31.76,-48,;29.77,-49.78,;29.14,-51.17,;27.61,-51.01,;27.3,-49.51,;25.96,-48.75,;25.96,-47.2,;27.29,-46.43,;27.29,-44.89,;28.63,-47.19,;28.63,-48.74,;34.69,-47.82,)| Show InChI	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	1.59E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of His6/TEV fused-GST-tagged Flt3 (unknown origin) (H564 to S993 residues) using Axltide (CKKSRGDYMTMQJ-acid) peptide as substrate preincu...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01904 BindingDB Entry DOI: 10.7270/Q2XP78NC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase receptor TYRO3 (Homo sapiens (Human))	BDBM50563641 (CHEMBL4744243) Show SMILES CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(Cl)cc13)C2 |(43.22,-48.73,;41.68,-48.73,;40.91,-50.06,;41.68,-51.39,;39.37,-50.05,;38.47,-48.8,;37,-49.27,;37,-50.81,;38.46,-51.29,;38.92,-52.75,;40.46,-52.75,;39.69,-54.09,;37.9,-53.9,;35.75,-48.36,;35.76,-46.82,;34.3,-46.34,;33.39,-47.59,;34.29,-48.83,;33.81,-50.3,;32.3,-50.61,;31.28,-49.46,;31.76,-48,;29.77,-49.78,;29.14,-51.17,;27.61,-51.01,;27.3,-49.51,;25.96,-48.75,;25.96,-47.2,;27.29,-46.43,;27.29,-44.89,;28.63,-47.19,;28.63,-48.74,;34.69,-47.82,)| Show InChI	PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	631	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged Tyro3 (unknown origin) (453 to 890 residues) using Axltide (KKSRGDYMTMQIG-acid) peptide as substrate preincubated for 30 min...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01904 BindingDB Entry DOI: 10.7270/Q2XP78NC
					More data for this Ligand-Target Pair
Tyrosine-protein kinase Mer (Homo sapiens (Human))	BDBM50563641 (CHEMBL4744243) Show SMILES CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(Cl)cc13)C2 |(43.22,-48.73,;41.68,-48.73,;40.91,-50.06,;41.68,-51.39,;39.37,-50.05,;38.47,-48.8,;37,-49.27,;37,-50.81,;38.46,-51.29,;38.92,-52.75,;40.46,-52.75,;39.69,-54.09,;37.9,-53.9,;35.75,-48.36,;35.76,-46.82,;34.3,-46.34,;33.39,-47.59,;34.29,-48.83,;33.81,-50.3,;32.3,-50.61,;31.28,-49.46,;31.76,-48,;29.77,-49.78,;29.14,-51.17,;27.61,-51.01,;27.3,-49.51,;25.96,-48.75,;25.96,-47.2,;27.29,-46.43,;27.29,-44.89,;28.63,-47.19,;28.63,-48.74,;34.69,-47.82,)| Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	PDB Article PubMed	n/a	n/a	25	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of 6His/thrombin cleavage site-fused Avi-tagged dephosphorylated MER (unknown origin) (R528 to M999 residues) using Axltide (CKKSRGDYMTMQJ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01904 BindingDB Entry DOI: 10.7270/Q2XP78NC
					More data for this Ligand-Target Pair				3D Structure (crystal)
Tyrosine-protein kinase receptor UFO (Homo sapiens (Human))	BDBM50563641 (CHEMBL4744243) Show SMILES CNC(=O)c1sc(nc1C(F)(F)F)N1CC2CC1(CNC(=O)c1c[nH]c3ncc(Cl)cc13)C2 |(43.22,-48.73,;41.68,-48.73,;40.91,-50.06,;41.68,-51.39,;39.37,-50.05,;38.47,-48.8,;37,-49.27,;37,-50.81,;38.46,-51.29,;38.92,-52.75,;40.46,-52.75,;39.69,-54.09,;37.9,-53.9,;35.75,-48.36,;35.76,-46.82,;34.3,-46.34,;33.39,-47.59,;34.29,-48.83,;33.81,-50.3,;32.3,-50.61,;31.28,-49.46,;31.76,-48,;29.77,-49.78,;29.14,-51.17,;27.61,-51.01,;27.3,-49.51,;25.96,-48.75,;25.96,-47.2,;27.29,-46.43,;27.29,-44.89,;28.63,-47.19,;28.63,-48.74,;34.69,-47.82,)| Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid PDB UniChem	Article PubMed	n/a	n/a	10	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of GST-tagged AXL (unknown origin) (464 to 485 residues) using Axltide (CKKSRGDYMTMQJG-acid) peptide as substrate preincubated for 30 mins...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01904 BindingDB Entry DOI: 10.7270/Q2XP78NC
					More data for this Ligand-Target Pair