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null

SMILES: CCc1ccc(CCC2CCc3nc(N)nc(N)c3N2C(=O)CCl)cc1

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50564145
Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	k_off s^-1	k_on M^-1s^-1	pH	Temp °C
Methionine synthase (Homo sapiens (Human))	BDBM50564145 (CHEMBL4778495) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Cobalamin-dependent methionine synthase isolated from HL-60 cells using methyltetrahydrofolate as substrate incubated for 10 mins...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112113 BindingDB Entry DOI: 10.7270/Q2DJ5KCQ
TBA					More data for this Ligand-Target Pair
Methionine synthase (Homo sapiens (Human))	BDBM50564145 (CHEMBL4778495) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	1.21E+4	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Cobalamin-dependent methionine synthase isolated from HL-60 cells using 252 uM of methyltetrahydrofolate as substrate incubated f...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112113 BindingDB Entry DOI: 10.7270/Q2DJ5KCQ
TBA					More data for this Ligand-Target Pair
Methionine synthase (Homo sapiens (Human))	BDBM50564145 (CHEMBL4778495) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	7.64E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Cobalamin-dependent methionine synthase isolated from HL-60 cells using 126 uM of methyltetrahydrofolate as substrate incubated f...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112113 BindingDB Entry DOI: 10.7270/Q2DJ5KCQ
TBA					More data for this Ligand-Target Pair
Methionine synthase (Homo sapiens (Human))	BDBM50564145 (CHEMBL4778495) Show SMILES Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	4.46E+3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of human Cobalamin-dependent methionine synthase isolated from HL-60 cells using 63 uM of methyltetrahydrofolate as substrate incubated fo...				Citation and Details Article DOI: 10.1016/j.ejmech.2020.112113 BindingDB Entry DOI: 10.7270/Q2DJ5KCQ
TBA					More data for this Ligand-Target Pair