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SMILES: Cn1c(nc2ccc(F)cc12)C(=O)c1cn(c2c(F)cccc12)S(=O)(=O)CCN1CCNCC1

InChI Key:

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50565597   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Proprotein convertase subtilisin/kexin type 9


(Homo sapiens (Human))		BDBM50565597
PNG
(CHEMBL4783880)
Show SMILES Cn1c(nc2ccc(F)cc12)C(=O)c1cn(c2c(F)cccc12)S(=O)(=O)CCN1CCNCC1
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 161n/an/an/an/a


TBA

Assay Description
Modulation of PCSK9 in human HepG2 cells assessed as reduction in PCSK9 expression incubated for 24 hrs prior to compound washout followed by compoun...

Citation and Details

Article DOI: 10.1016/j.ejmech.2020.112678
BindingDB Entry DOI: 10.7270/Q2F193GX
More data for this
Ligand-Target Pair