null

SMILES: CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(Cl)nc3)o2)c(O)c1-c1c(OC)cccc1OC

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50570426   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Apelin receptor (Rattus norvegicus)	BDBM50570426 (CHEMBL4876050) Show SMILES CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(Cl)nc3)o2)c(O)c1-c1c(OC)cccc1OC |(.83,-34.32,;2.17,-35.08,;3.5,-34.31,;4.84,-35.07,;6.17,-34.29,;6.16,-32.75,;7.49,-31.97,;7.49,-30.43,;8.83,-32.74,;10.16,-31.97,;10.31,-30.43,;11.82,-30.11,;12.59,-31.44,;14.13,-31.6,;14.76,-33,;16.28,-33.15,;16.91,-34.55,;16.01,-35.81,;16.64,-37.22,;14.48,-35.65,;13.85,-34.25,;11.57,-32.59,;8.83,-34.28,;10.16,-35.05,;7.5,-35.05,;7.51,-36.59,;6.18,-37.36,;4.85,-36.59,;3.52,-37.36,;6.18,-38.9,;7.51,-39.67,;8.85,-38.9,;8.84,-37.35,;10.18,-36.58,;11.51,-37.35,)| Show InChI	PDB UniProtKB/SwissProt GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.580	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at rat APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 hr...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01878 BindingDB Entry DOI: 10.7270/Q20G3PXZ
					More data for this Ligand-Target Pair
Apelin receptor (Homo sapiens (Human))	BDBM50570426 (CHEMBL4876050) Show SMILES CCOCc1[nH]c(=O)c(-c2nnc(Cc3ccc(Cl)nc3)o2)c(O)c1-c1c(OC)cccc1OC |(.83,-34.32,;2.17,-35.08,;3.5,-34.31,;4.84,-35.07,;6.17,-34.29,;6.16,-32.75,;7.49,-31.97,;7.49,-30.43,;8.83,-32.74,;10.16,-31.97,;10.31,-30.43,;11.82,-30.11,;12.59,-31.44,;14.13,-31.6,;14.76,-33,;16.28,-33.15,;16.91,-34.55,;16.01,-35.81,;16.64,-37.22,;14.48,-35.65,;13.85,-34.25,;11.57,-32.59,;8.83,-34.28,;10.16,-35.05,;7.5,-35.05,;7.51,-36.59,;6.18,-37.36,;4.85,-36.59,;3.52,-37.36,;6.18,-38.9,;7.51,-39.67,;8.85,-38.9,;8.84,-37.35,;10.18,-36.58,;11.51,-37.35,)| Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	n/a	n/a	0.170	n/a	n/a	n/a	n/a
TBA					Assay Description Agonist activity at human APJ receptor expressed in human HEK293 cells assessed as inhibition of forskolin-induced cAMP accumulation incubated for 1 ...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01878 BindingDB Entry DOI: 10.7270/Q20G3PXZ
					More data for this Ligand-Target Pair