BindingDB logo
myBDB logout

null

SMILES: Cc1cc2occ(-c3nc(c(-c4ccccc4)n3-c3ccc(Cl)c(Cl)c3)-c3ccccc3)c(=O)c2cc1Cl

InChI Key:

Find this compound or compounds like it in BindingDB or PDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50570431   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50/IC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
DNA topoisomerase 2-alpha


(Homo sapiens (Human))		BDBM50570431
PNG
(CHEMBL4869150)
Show SMILES Cc1cc2occ(-c3nc(c(-c4ccccc4)n3-c3ccc(Cl)c(Cl)c3)-c3ccccc3)c(=O)c2cc1Cl
PDB

UniProtKB/SwissProt

antibodypedia
GoogleScholar
AffyNet 
PC cid
PC sid
UniChem
Article
PubMed
n/an/a 3.99E+4n/an/an/an/an/an/a


TBA

Assay Description
Inhibition of human topoisomerase-2 alpha in human A498 cells assessed as decrease in relaxation of supercoiled DNA at 10 uM

Citation and Details

Article DOI: 10.1016/j.bmcl.2021.127916
BindingDB Entry DOI: 10.7270/Q2VQ36GH
More data for this
Ligand-Target Pair