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SMILES: CC(C)n1cc(cn1)-c1nc(Nc2ccc3N(CCc3c2)C(=O)CN2CCS(=O)(=O)CC2)ncc1C

InChI Key:

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50572374   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM50572374 (CHEMBL4862108) Show SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc3N(CCc3c2)C(=O)CN2CCS(=O)(=O)CC2)ncc1C Show InChI	PDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	2	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human TYK2 (875 to end residues) using GGMEDIYFEFMGG as substrate incubated for 40 mins in presence of [gamma33P]ATP by sci...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01468 BindingDB Entry DOI: 10.7270/Q23N2750
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM50572374 (CHEMBL4862108) Show SMILES CC(C)n1cc(cn1)-c1nc(Nc2ccc3N(CCc3c2)C(=O)CN2CCS(=O)(=O)CC2)ncc1C Show InChI	PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	Article PubMed	n/a	n/a	3	n/a	n/a	n/a	n/a	n/a	n/a
TBA					Assay Description Inhibition of recombinant human JAK2 (808 to end residues) KTFCGTPEYLAPE as substrate measured after 40 mins in presence of [gamm33P]ATP by scintilla...				Citation and Details Article DOI: 10.1021/acs.jmedchem.0c01468 BindingDB Entry DOI: 10.7270/Q23N2750
					More data for this Ligand-Target Pair