null
SMILES: Cc1cc(C)c(CNC(=O)c2cc(cc3N(CCc23)C(=O)C2CCCC2)-c2ccc(CN3CCOCC3)cc2)c(=O)[nH]1
InChI Key:
Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM50575209 (CHEMBL4875308) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | >1.00E+4 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of EZH2 Y641F mutant (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01154 BindingDB Entry DOI: 10.7270/Q2D79G73 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Histone-lysine N-methyltransferase EZH2 (Homo sapiens (Human)) | BDBM50575209 (CHEMBL4875308) | PDB KEGG UniProtKB/SwissProt B.MOAD antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem | Article PubMed | n/a | n/a | 394 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA | Assay Description Inhibition of EZH2 (unknown origin) using SAM as substrate incubated for 60 mins by luminescence microplate reader assay | Citation and Details Article DOI: 10.1021/acs.jmedchem.1c01154 BindingDB Entry DOI: 10.7270/Q2D79G73 | |||||||||||
More data for this Ligand-Target Pair |