Found 3 hits for monomerid = 50575904 Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kcal/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
Phosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50575904
(CHEMBL4870367)Show SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)[C@@H]3C[C@@H](C3)OC)ncnc12)-c1cnc(C)nc1 |r,wU:15.15,17.20,wD:8.7,(21.37,-48.31,;22.88,-47.98,;23.34,-46.51,;22.43,-45.28,;23.32,-44.03,;24.79,-44.5,;26.13,-43.72,;26.12,-42.18,;27.45,-41.4,;28.85,-42.02,;29.87,-40.87,;29.1,-39.54,;27.59,-39.86,;29.72,-38.13,;28.81,-36.89,;31.24,-37.96,;32.44,-38.92,;33.41,-37.72,;32.2,-36.76,;34.94,-37.55,;35.85,-38.79,;27.46,-44.47,;27.47,-46.01,;26.14,-46.79,;24.8,-46.03,;20.89,-45.29,;20.12,-43.96,;18.66,-43.88,;17.82,-45.31,;16.28,-45.32,;18.6,-46.64,;20.14,-46.62,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 2.80 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of N-terminal His6-tagged recombinant full length human p110delta/untagged recombinant full length human p85alpha expressed in baculovirus... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00237 BindingDB Entry DOI: 10.7270/Q28919NT |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50575904
(CHEMBL4870367)Show SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)[C@@H]3C[C@@H](C3)OC)ncnc12)-c1cnc(C)nc1 |r,wU:15.15,17.20,wD:8.7,(21.37,-48.31,;22.88,-47.98,;23.34,-46.51,;22.43,-45.28,;23.32,-44.03,;24.79,-44.5,;26.13,-43.72,;26.12,-42.18,;27.45,-41.4,;28.85,-42.02,;29.87,-40.87,;29.1,-39.54,;27.59,-39.86,;29.72,-38.13,;28.81,-36.89,;31.24,-37.96,;32.44,-38.92,;33.41,-37.72,;32.2,-36.76,;34.94,-37.55,;35.85,-38.79,;27.46,-44.47,;27.47,-46.01,;26.14,-46.79,;24.8,-46.03,;20.89,-45.29,;20.12,-43.96,;18.66,-43.88,;17.82,-45.31,;16.28,-45.32,;18.6,-46.64,;20.14,-46.62,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 75 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-CD79b antibody-induced CD69 expression preincubated for 60 mins followed b... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00237 BindingDB Entry DOI: 10.7270/Q28919NT |
More data for this Ligand-Target Pair | |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
(Homo sapiens (Human)) | BDBM50575904
(CHEMBL4870367)Show SMILES CCn1c(nc2c(O[C@H]3CCN(C3)C(=O)[C@@H]3C[C@@H](C3)OC)ncnc12)-c1cnc(C)nc1 |r,wU:15.15,17.20,wD:8.7,(21.37,-48.31,;22.88,-47.98,;23.34,-46.51,;22.43,-45.28,;23.32,-44.03,;24.79,-44.5,;26.13,-43.72,;26.12,-42.18,;27.45,-41.4,;28.85,-42.02,;29.87,-40.87,;29.1,-39.54,;27.59,-39.86,;29.72,-38.13,;28.81,-36.89,;31.24,-37.96,;32.44,-38.92,;33.41,-37.72,;32.2,-36.76,;34.94,-37.55,;35.85,-38.79,;27.46,-44.47,;27.47,-46.01,;26.14,-46.79,;24.8,-46.03,;20.89,-45.29,;20.12,-43.96,;18.66,-43.88,;17.82,-45.31,;16.28,-45.32,;18.6,-46.64,;20.14,-46.62,)| | PDB MMDB
NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar AffyNet
| PC cid PC sid UniChem
| Article PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
TBA
| Assay Description Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in anti-IgM-antibody-induced phosphorylation of AKT at Ser473 residue preincubated... |
Citation and Details
Article DOI: 10.1021/acs.jmedchem.1c00237 BindingDB Entry DOI: 10.7270/Q28919NT |
More data for this Ligand-Target Pair | |